Interstitial pneumonia induced by sorafenib in a patient with hepatocellular carcinoma: An autopsy case report

Oncology Letters
Takashi YamaguchiKazuichi Okazaki

Abstract

Sorafenib is a multikinase inhibitor currently approved in Japan for the treatment of unresectable hepatocellular carcinoma. Interstitial pneumonia induced by sorafenib may have a fatal outcome, and therefore, has recently been the focus of many studies. The current report presents an autopsy case of diffuse alveolar damage (DAD) that occurred in a 59-year-old male, who had been treated with sorafenib. The patient had been given sorafenib for six months and had exhibited no respiratory symptoms during this time. However, 19 days after sorafenib treatment was resumed, acute interstitial pneumonia developed. In previously reported cases, the first symptoms of pulmonary toxicity appeared following a limited treatment duration with sorafenib; this was in contrast to the patient in the current study, who developed the first symptoms after eight months. We therefore conclude that physicians must be aware of interstitial pneumonia as a potential pulmonary toxicity associated with sorafenib treatment when treatment with sorafenib is resumed, even after prolonged use. In addition, to best of our knowledge, this is the first case of a postmortem examination reported in patient with interstitial pneumonia induced by sorafenib treatment.

References

Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Sep 2, 2004·British Journal of Cancer·N L MüllerA Gemma
Sep 24, 2004·Annals of Internal Medicine·Andrés EstebanFernando Ríos
Jan 11, 2005·The European Respiratory Journal·Y AbadieC Delclaux
Feb 12, 2008·Chest·Massimo Zambon, Jean-Louis Vincent
Dec 5, 2008·Histopathology·Jeffrey L Myers, Anna-Luise A Katzenstein
Nov 10, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shotaro IdeShigeru Kohno
Nov 15, 2011·Targeted Oncology·Nicholas A Barber, Apar Kishor Ganti
Aug 17, 2012·The Open Respiratory Medicine Journal·Martin SchwaiblmairThomas Berghaus

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Citations

Jan 5, 2017·Internal Medicine·Shotaro IdeHiroshi Mukae
Jul 12, 2018·Expert Review of Anticancer Therapy·Li LiYohannes T Ghebre
Nov 9, 2017·Investigational New Drugs·Valentina GiglioGraziella Vecchio
Apr 8, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Tomoko FunahashiMitsunobu R Kano

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Methods Mentioned

BETA
X-ray

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Carcinoma, Hepatocellular

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