PMID: 8947543Nov 1, 1996Paper

Interstitial radiation and hyperthermia in the Dunning R3327 prostate tumour model: therapeutic efficacy depends on radiation dose-rate, sequence and frequency of heating

International Journal of Radiation Biology
Peter PeschkeI Zuna

Abstract

To determine the most effective means by which to apply the combined treatments of local tumour hyperthermia (LTH) with interstitial low dose-rate irradiation (IRT) we examined the significance of such factors as dose-rate of radiation, and the sequence and frequency of hyperthermia applications in the anaplastic Dunning prostate tumour subline R3327-AT1. IRT was carried out by the insertion of a single Ir-192 seed into the center of the tumour. For LTH treatments, the tumour-bearing leg was positioned in a circulating constant temperature water bath (43.5 +/- 0.1 degrees C) for 35 min. Neither LTH treatment alone nor the insertion of a dummy seed produced any change in tumour growth compared with sham-treated controls. With regard to the sequence of heating and IRT our results showed that during a 72-h treatment time (30 Gy, 40 cGy/h) a single heat treatment given just before the start of IRT was more efficient (TER = 1.47) in terms of growth delay than LTH given in the middle or the end of radiation treatment (TER approximately 1.0). The growth delay for both the 20 and 40 cGy/h groups appear to be linear with increasing dose for the IRT as well as the IRT + LTH groups. The higher dose-rate was more effective especially with ...Continue Reading

References

Oct 1, 1978·Radiology·L HarisiadisE J Hall
Mar 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C T CoughlinR Jeffery
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J Overgaard
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·Z PetrovichJ Slater
Jul 1, 1989·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·E L JonesB J Dain
Nov 1, 1988·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J MooibroekH Jung
Jan 1, 1988·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·E Dikomey, H Jung
Nov 1, 1987·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C W SongS H Levitt
Apr 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G G SteelT C Stephens
Apr 1, 1985·The British Journal of Radiology·I J SpiroJ Gaskill
Mar 1, 1973·The British Journal of Radiology·R P Hill, R S Bush
Nov 1, 1984·International Journal of Radiation Oncology, Biology, Physics·C R MoorthyB S Hilaris
Nov 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C A van GeelP C Levendag
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·B SteaJ R Cassady
May 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D S Kapp
Apr 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R P MasonE W Hahn
Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·M KleineidamH P Beck-Bornholdt
Sep 1, 1996·International Journal of Radiation Oncology, Biology, Physics·K HenkeE W Hahn

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Citations

Apr 28, 2006·International Journal of Radiation Biology·Wolfgang HarmsPeter Peschke
Dec 23, 2000·The Journal of Urology·R N CoffeyJ M Fitzpatrick
Apr 9, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Andrzej Marek KukiełkaKrzysztof Bereza
Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·P HuberJ Debus
Jul 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Stephanie SolazzoS Nahum Goldberg
Dec 10, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·A M KukiełkaM Reinfuss
Apr 23, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·A M KukiełkaR Kudzia
May 3, 2000·Journal of Biomechanical Engineering·S BhowmickJ C Bischof

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