PMID: 8948644Nov 15, 1996Paper

Interstrand cross-linking reaction in triplexes containing a monofunctional transplatin-adduct

Nucleic Acids Research
C ColombierM Leng

Abstract

Our aim was to determine whether a single transplatin monofunctional adduct, either trans-[Pt(NH3)2(dC)Cl]+ or trans-[Pt(NH3)2(dG)Cl]+ within a homopyrimidine oligonucleotide, could further react and form an interstrand cross-link once the platinated oligonucleotide was bound to the complementary duplex. The single monofunctional adduct was located at either the 5' end or in the middle of the platinated oligonucleotide. In all the triplexes, specific interstrand cross-links were formed between the platinated Hoogsteen strand and the complementary purine-rich strand. No interstrand cross-links were detected between the platinated oligonucleotides and non-complementary DNA. The yield and the rate of the cross-linking reaction depend upon the nature and location of the monofunctional adducts. Half-lives of the monofunctional adducts within the triplexes were in the range 2-6 h. The potential use of the platinated oligonucleotides to modulate gene expression is discussed.

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Citations

Jun 20, 2001·Chemistry : a European Journal·M S LüthB Lippert
Apr 8, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Meghan A Campbell, Paul S Miller
Dec 3, 2009·Bioconjugate Chemistry·Meghan A Campbell, Paul S Miller
Jun 29, 2010·Chemical Research in Toxicology·Lu RaoUlrich Bierbach
Sep 12, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Mindy K Graham, Paul S Miller
Aug 27, 2003·Medicinal Research Reviews·Li-June Ming
Oct 2, 2004·Journal of Inorganic Biochemistry·Sunil K Sharma, Larry W McLaughlin
Apr 27, 2016·Chemistry : a European Journal·Dattatraya UkaleTuomas Lönnberg
Mar 27, 2018·Chembiochem : a European Journal of Chemical Biology·Dattatraya Uttam Ukale, Tuomas Lönnberg
Dec 12, 2017·Chemistry : a European Journal·Sajal Kumar Maity, Tuomas Lönnberg
Oct 26, 2018·Angewandte Chemie·Dattatraya Uttam Ukale, Tuomas Lönnberg
Mar 29, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Madhuri HandeTuomas Lönnberg
Jul 2, 2019·Angewandte Chemie·Shuvankar NaskarJens Müller
Dec 22, 2019·International Journal of Molecular Sciences·Toshifumi KishimotoSeiji Komeda
May 31, 2018·International Journal of Molecular Sciences·Madhuri HandeTuomas Lönnberg
May 12, 2000·Biochimica Et Biophysica Acta·D PraseuthC Hélène
Aug 15, 2002·Journal of the American Chemical Society·Sunil K Sharma, Larry W McLaughlin

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