Intertest variability of mfVEP amplitude: reducing its effect on the interpretation of sequential tests

Documenta Ophthalmologica. Advances in Ophthalmology
Alexander Klistorner, S Graham

Abstract

The multi-focal visual evoked potential (mfVEP) has been recently introduced as an alternative to subjective perimetry in detecting visual field defects. This study examines the source of variability in the mfVEP amplitude, and determines the relationship of this variability to the strength of the signal itself across the visual field. It also investigates possible means to reduce the effects of this variability on between-test interpretation to allow for easier detection of progression. 85 normal subjects participated in the study. The mfVEP was recorded using Accumap (ObjectiVision Pty Ltd, Sydney, Australia). Each subject was tested twice with an interval between visits of 3-4 weeks. Comparison between tests was performed using coefficient of variability (CV). Variability was also analysed using scaling and clustering procedures. In the majority of the retinal areas CV fell within 15-20%. Variability increased with eccentricity, but there was no age dependency. There was a significant reduction of variability (by 15.8 +/- 6%, Student's t-test p<0.0001) when a scaling procedure was applied and this was consistent at all eccentricities. A clustering procedure reduced variability on average by a further 18.5 +/- 4.5% (Student's...Continue Reading

References

Jul 31, 1998·Australian and New Zealand Journal of Ophthalmology·A I KlistornerF A Billson
Jul 23, 1999·Survey of Ophthalmology·S L GrahamF A Billson
Mar 9, 2000·Journal of Glaucoma·S L GrahamF A Billson
Nov 30, 2000·Ophthalmology·A Klistorner, S L Graham
Jan 5, 2002·American Journal of Ophthalmology·Ivan GoldbergAlexander I Klistorner
Jan 31, 2003·Investigative Ophthalmology & Visual Science·Andrew Charles James
Feb 27, 2003·Progress in Retinal and Eye Research·Donald C Hood, Vivienne C Greenstein
Jul 2, 2003·American Journal of Ophthalmology·Phamornsak ThienprasiddhiDonald C Hood
Oct 2, 2003·Journal of Glaucoma·Candice S ChenVivienne C Greenstein
Oct 27, 2004·Investigative Ophthalmology & Visual Science·Anne BjerreDavid B Henson
May 11, 2005·Documenta Ophthalmologica. Advances in Ophthalmology·Donald C HoodChris A Johnson
Jun 1, 2005·The British Journal of Ophthalmology·A I KlistornerC Balachandran
Sep 27, 2005·Clinical & Experimental Ophthalmology·Alessandra MartinsFrank Billson

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Citations

Aug 8, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Alexander KlistornerHemamalini Arvind
Sep 10, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Alexander KlistornerC Yiannikas
Oct 3, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Boonchai WangsupadilokDonald C Hood
Dec 10, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Michal LaronLaura J Frishman
Aug 20, 2008·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Omar S PunjabiShan C Lin

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