Intertwined regulation of angiogenesis and immunity by myeloid cells

Trends in Immunology
Lee B Rivera, Gabriele Bergers

Abstract

Angiogenesis is a hallmark of cancer because its induction is indispensable to fuel an expanding tumor. The tumor microenvironment contributes to tumor vessel growth, and distinct myeloid cells recruited by the tumor have been shown not only to support angiogenesis but also to foster an immune suppressive environment that supports tumor expansion and progression. Recent findings suggest that the intertwined regulation of angiogenesis and immune modulation can offer therapeutic opportunities for the treatment of cancer. We review the mechanisms by which distinct myeloid cell populations contribute to tumor angiogenesis, discuss current approaches in the clinic that are targeting both angiogenic and immune suppressive pathways, and highlight important areas of future research.

References

Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Sep 27, 2000·Neoplasia : an International Journal for Oncology Research·J L RubensteinM A Shuman
Jun 5, 2003·Nature Reviews. Cancer·Gabriele Bergers, Laura E Benjamin
Jun 5, 2003·Nature Reviews. Cancer·Raghu Kalluri
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jul 16, 2003·Cold Spring Harbor Symposia on Quantitative Biology·R K Jain
Sep 6, 2003·Cancer Cell·Barbara BlouwGabriele Bergers
Sep 30, 2003·The Journal of Biological Chemistry·Ling WangDebabrata Mukhopadhyay
Jun 23, 2004·Cytokine & Growth Factor Reviews·Christer Betsholtz
Sep 3, 2004·The Journal of Clinical Investigation·Enrico GiraudoDouglas Hanahan
Jan 22, 2005·Current Opinion in Genetics & Development·Peter BalukDonald M McDonald
Dec 16, 2005·Nature·Peter Carmeliet
Nov 23, 2006·Cancer Research·Elaine Y LinJeffrey W Pollard
Jul 3, 2007·Cancer Metastasis Reviews·Debbie Liao, Randall S Johnson
Aug 1, 2007·Nature Biotechnology·Farbod ShojaeiNapoleone Ferrara
Nov 6, 2007·Trends in Immunology·Michele De PalmaClaire E Lewis
Jul 18, 2008·Nature Reviews. Cancer·Craig MurdochClaire E Lewis
Sep 9, 2008·The Journal of Clinical Investigation·Maciej KujawskiHua Yu
Feb 13, 2009·Oncology Reports·Tohru IshikawaHiroyuki Hamakawa
Apr 1, 2009·Nature Reviews. Clinical Oncology·Elizabeth R GerstnerTracy T Batchelor
Jun 2, 2009·Nature Reviews. Clinical Oncology·Rakesh K JainA Gregory Sorensen
Jun 3, 2009·The Oncologist·Andrew S ChiTracy T Batchelor
Jun 25, 2010·Nature Reviews. Cancer·Alicia S ChungNapoleone Ferrara
Mar 3, 2011·Nature Reviews. Clinical Oncology·John M L Ebos, Robert S Kerbel
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 30, 2011·International Journal of Cancer. Journal International Du Cancer·Apostolos C ZiogasAristotle Bamias

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Citations

Apr 19, 2016·Trends in Cancer·Dolores Hambardzumyan, Gabriele Bergers
May 9, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Elisabeth J M HuijbersArjan W Griffioen
Jun 12, 2016·Pharmacology & Therapeutics·Beverly L FalconBronislaw Pytowski
Sep 16, 2016·Frontiers in Immunology·Peter Vaupel, Gabriele Multhoff
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Madelon Q WentinkPeter Timmerman
Apr 11, 2018·Immunology and Cell Biology·Salman M Toor, Eyad Elkord
May 17, 2018·Angiogenesis·Patrycja Nowak-SliwinskaArjan W Griffioen
Aug 31, 2018·International Journal of Molecular Sciences·Benjamin W JohnsonAli S Arbab
Oct 31, 2018·Seminars in Immunopathology·Emmett V Schmidt
Feb 19, 2019·Journal of Leukocyte Biology·Claire E OlingyCatherine C Hedrick
Oct 31, 2018·Virchows Archiv : an International Journal of Pathology·Alessandra TuccittoViviana Vallacchi
Sep 11, 2019·International Journal of Molecular Sciences·Gilda VarricchiStephen J Galli
Oct 2, 2019·Frontiers in Immunology·Yichao Hua, Gabriele Bergers
Oct 11, 2019·International Journal of Molecular Sciences·Javier PozasJavier Molina-Cerrillo
May 1, 2019·International Journal of Molecular Sciences·Giuseppe SammarcoRiccardo Memeo
Jan 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shanawaz M GhouseMaciej M Markiewski
Feb 19, 2020·Journal of Leukocyte Biology·Anne M Hahn, Thomas H Winkler
Feb 23, 2020·The Journal of Pathology·Tim Beltraminelli, Michele De Palma
Sep 11, 2019·Cold Spring Harbor Perspectives in Medicine·Asmaa El-KenawiBrian Ruffell
May 14, 2020·Journal of Cellular Physiology·XiangHua HanPeter C Brooks
Jul 30, 2015·The Cancer Journal·Zena Werb, Pengfei Lu
Oct 19, 2016·Current Opinion in Hematology·Cédric Seignez, Mia Phillipson
Sep 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Keehoon JungDai Fukumura
Jun 17, 2018·Journal of Neuroinflammation·Joy E TomlinsonJonathan Cheetham
Jun 2, 2016·International Journal of Molecular Medicine·Masaru Katoh
Apr 2, 2020·Journal of Clinical Medicine·Alessia MennittoElena Verzoni
Jan 11, 2019·Frontiers in Immunology·Maria GeorganakiAnna Dimberg
Apr 14, 2017·Science Translational Medicine·Martina SchmittnaegelMichele De Palma
Jul 12, 2017·The Journal of Clinical Investigation·Keehoon JungDai Fukumura
Dec 3, 2016·Gynecologic Oncology Research and Practice·Stéphanie L GaillardBradley Monk
Nov 11, 2015·Cancer Discovery·Amanda W LundLisa M Coussens
Dec 23, 2016·Cancer Immunology Research·Xinqi WuF Stephen Hodi
Jun 12, 2020·Seminars in Cancer Biology·Aaron T CinerPnina Brodt
Jan 24, 2021·Expert Opinion on Therapeutic Targets·Hans-Georg WirschingMichael Weller

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