Intervention after PSA failure: examination of intervention time and subsequent outcomes from a prospective patient database

International Journal of Radiation Oncology, Biology, Physics
Charmaine Kim-SingProstate Cohort Outcomes Initiative

Abstract

To investigate timing of intervention for solitary biochemical relapse following external beam radiation therapy (EBRT) for localized prostate cancer, and to assess the impact on survival. Of 1499 men treated with EBRT from 1994 to 2000, 544 men had prostate-specific antigen (PSA) relapse by the Vancouver Criteria. Patients with near-simultaneous clinical relapse (n = 79) were excluded, leaving 465 for analysis. Pretreatment prognostic factors, the time that biochemical relapse was realized (trigger PSA time), and postrelapse doubling time (PSAdt) were examined for effect on the timing of intervention and cause-specific survival (CSS). Median actuarial time from trigger-PSA time to intervention was 30 months. The only factor associated with early intervention on multivariate analysis (MVA) was faster PSAdt (p < 0.0001). Not significant were initial PSA, Gleason score, T stage, or adjuvant androgen ablation use or duration. Seventy-five percent of interventions occurred with PSAdt faster than 12 months. The 5-year CSS was 89%. Faster PSAdt (p = 0.0007), higher Gleason score (p = 0.018), and earlier intervention (p = 0.0006) were significantly associated with increased prostate cancer death on MVA. The 5-year CSS is 19% where the...Continue Reading

References

May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A L ZietmanW U Shipley
May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Patrick A KupelianEric A Klein
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Gillian M DuchesneRoss Snow
May 31, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony V D'AmicoMing-Hui Chen
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Alan PollackEric M Horwitz

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Citations

Sep 26, 2006·Der Urologe. Ausg. A·J E Altwein, T Ebert
Aug 25, 2005·Disease Management : DM·A Simon PickardCharles L Bennett
Aug 16, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M T SchweizerE S Antonarakis
Apr 27, 2013·Current Opinion in Urology·Detlef BartkowiakThomas Wiegel
May 8, 2013·Future Oncology·Detlef BartkowiakThomas Wiegel
Nov 4, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniel E SotoHoward M Sandler
May 23, 2008·International Journal of Radiation Oncology, Biology, Physics·Daniel E SotoCharlie C Pan
Sep 3, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L Quero, C Hennequin
Sep 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Winkle KwanChuck Paltiel
Apr 4, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Andrew LoblawUNKNOWN American Society of Clinical Oncology
Apr 24, 2017·Current Treatment Options in Oncology·Farhad FakhrejahaniWilliam L Dahut

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