Intervention to reduce carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit.

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Anucha ThatrimontrichaiAnucha Apisarnthanarak

Abstract

To investigate the effects of environmental cleaning and the installation of heat and moisture exchangers (HMEs) to reduce neonatal carbapenem-resistant Acinetobacter baumannii (CRAB) sepsis and colonization as well as antimicrobial use. We conducted a 7-year, quasi-experimental study. All neonates admitted to a neonatal intensive care unit (NICU). We compared the trends for CRAB sepsis and colonization before (period 1, 2011-2013) and after (period 3, 2015-2017) a 12-month intervention period in 2014 (period 2) to incorporate a combination of HME use and sodium hypochlorite cleaning (5,000 ppm in the NICU and 500 ppm in the neonatal environment) using interrupted time series analysis with segmented regression. During the 7-year study period, 3,367 neonates were admitted to the NICU; the prevalence rates of CRAB sepsis and endotracheal CRAB colonization were 0.5 per 1,000 patient days, and 19.4 per 1,000 ventilator days. A comparison of period 1 to period 3 showed significant decreases in the percentages of both CRAB of A. baumannii sepsis (100% versus 11%) and endotracheal colonization (76% vs 52%) following the introduction of disposable HMEs and sodium hypochlorite cleaning (both P < .001). In period 3, compared with period ...Continue Reading

References

Aug 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anucha ApisarnthanarakUNKNOWN Thammasat University Pandrug-Resistant Acinetobacter baumannii Control Group
Sep 1, 2012·The Pediatric Infectious Disease Journal·Anucha ThatrimontrichaiGunlawadee Maneenil
Dec 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anucha Apisarnthanarak, David K Warren
Jan 13, 2015·American Journal of Infection Control·Margaret A DudeckDawn M Sievert
May 28, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Anucha ThatrimontrichaiPattama Tanaanantarak
Oct 16, 2016·American Journal of Infection Control·Víctor Daniel RosenthalUNKNOWN Remaining authors
Jan 26, 2017·World Journal of Pediatrics : WJP·Anucha ThatrimontrichaiPattama Tanaanantarak
May 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anucha ApisarnthanarakM Todd Greene
May 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nattawat TeerawattanapongNathorn Chaiyakunapruk
Sep 20, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Anucha ApisarnthanarakLance R Peterson
Feb 18, 2020·Journal of Infection in Developing Countries·Anucha ThatrimontrichaiGunlawadee Maneenil

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Citations

Aug 19, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Carlos Rodríguez-LucasJavier Fernández
Jul 15, 2021·The Pediatric Infectious Disease Journal·Anucha ThatrimontrichaiManapat Phatigomet

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