Intervention with the crude polysaccharides of Physalis pubescens L. mitigates colitis by preventing oxidative damage, aberrant immune responses, and dysbacteriosis.

Journal of Food Science
Xiuli ZhaoShuo Wang

Abstract

In this study, a colitis mouse model induced by dextran sulfate sodium (DSS) was used to investigate the mechanisms of action of an extract of crude polysaccharides (POL) from Physalis pubescens L. as a dietary intervention for colitis. Our results showed that the administration of POL prior to DSS-induced colitis protected the colon mucosal layer; maintained intestinal barrier integrity; alleviated oxidative damage; and lowered neutrophil infiltration by downregulating intercellular cell adhesion molecule-1 and monocyte chemoattractant protein-1 expression. More importantly, POL pretreatment reduced the expression of the proinflammatory factors tumor necrosis factor-α, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), thereby modulating the nuclear factor-κB/iNOS-COX-2 signal transduction pathway. In addition, POL reversed DSS-induced gut dysbiosis, accompanied by reducing the relative abundance of Helicobacter, Mucispirillum, and Erysipelatoclostridium. In conclusion, POL ameliorated DSS-induced intestinal injury in mice, indicating that POL could be a useful dietary nutrient to protect against colitis. PRACTICAL APPLICATION: Physalis pubescens L. is an edible fruit. The results of this study show that the...Continue Reading

References

Aug 21, 2002·The Journal of Experimental Medicine·Marika C KullbergAlan Sher
Feb 4, 2003·Alimentary Pharmacology & Therapeutics·J Goh, C A O'Morain
Apr 21, 2005·Molecular Nutrition & Food Research·Julio GalvezAntonio Zarzuelo
Oct 6, 2005·Biochemical and Biophysical Research Communications·Ki Han KwonHajime Ohigashi
Jan 24, 2006·International Immunopharmacology·Igor A Schepetkin, Mark T Quinn
Jul 13, 2006·Gastroenterology·Maria Van der SluisAlexandra W C Einerhand
Apr 4, 2007·Digestive Diseases and Sciences·Ali RezaieMohammad Abdollahi
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Trine OlsenJon Florholmen
Jan 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michio OnizawaMamoru Watanabe
Aug 23, 2011·Pharmacological Reports : PR·Anand B Pithadia, Sunita Jain
Feb 22, 2012·Nature Reviews. Gastroenterology & Hepatology·Indrani MukhopadhyaGeorgina L Hold
Mar 15, 2012·Journal of Gastroenterology and Hepatology·Yoon Jae KimKi Baik Hahm
Aug 22, 2012·Nature Reviews. Gastroenterology & Hepatology·Chaysavanh ManichanhFrancisco Guarner
Feb 11, 2014·Current Protocols in Immunology·Benoit ChassaingMatam Vijay-Kumar
Aug 30, 2014·Helicobacter·Leonardo H EusebiFranco Bazzoli
Jan 30, 2015·Molecular Nutrition & Food Research·Ma Pilar UtrillaLuis A Rubio
Aug 11, 2015·Journal of Autoimmunity·Katrina M de Lange, Jeffrey C Barrett
Sep 26, 2015·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Al C MoldoveanuCarmen Fierbinteanu Braticevici
Feb 18, 2016·The Journal of Nutritional Biochemistry·Jennifer M MonkKrista A Power
Nov 20, 2016·The Journal of Nutritional Biochemistry·Yifei KangMei-Jun Zhu
Feb 12, 2017·International Journal of Biological Macromolecules·Jun LvPeiyuan Xia
Sep 15, 2017·Indian Journal of Microbiology·Zhibing QiuLiang Zhong
May 28, 2019·Molecular Nutrition & Food Research·Qiuhui HuHang Xiao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Leadership & Management Review : the Journal of CLMA
Cathy J Kenny
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Xu Liang, Wang Bing
Current Protocols in Immunology
Benoit ChassaingMatam Vijay-Kumar
© 2021 Meta ULC. All rights reserved