PMID: 9646779Jul 1, 1998Paper

Interventional use of plasminogen activators in central nervous system diseases

The Medical Clinics of North America
G J del Zoppo, A A Sasahara

Abstract

Still an experimental approach, the direct intra-arterial infusion of plasminogen activators in the setting of acute thrombotic stroke has received impetus from successful clinical trials of intravenous infusion therapy. Direct therapy, employing catheter delivery, has successfully produced evidence of recanalization in carotid artery territory and vertebrobasilar artery territory thrombotic occlusions. One very recent prospective randomized study has demonstrated the success and limitations of this approach. Attention to safety concerns will be important to the future success of direct intra-arterial delivery of plasminogen activators in acute thrombotic stroke.

References

May 1, 1978·British Medical Bulletin·V V Kakkar, M F Scully
Dec 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·C M Fisher
May 1, 1977·Stroke; a Journal of Cerebral Circulation·C R Archer, S Horenstein
Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·J M Wardlaw, C P Warlow
Apr 15, 1992·American Journal of Ophthalmology·D SchmidtA K Wakhloo
Jul 1, 1992·Annals of Neurology·G J del ZoppoO Busse
Dec 1, 1991·Seminars in Neurology·G J del ZoppoW Hacke
Aug 1, 1990·Clinical Neuropharmacology·M S PessinC J Estol
Jul 1, 1989·Journal of the Neurological Sciences·C FieschiL Bozzao
Nov 1, 1989·Stroke; a Journal of Cerebral Circulation·V L BabikianP B Gorelick
May 1, 1989·Stroke; a Journal of Cerebral Circulation·Y OkadaT Omae
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·J OgataT Yamaguchi
Sep 1, 1989·AJR. American Journal of Roentgenology·R T HigashidaG B Hieshima
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M S RungeE Haber
Nov 1, 1988·Annals of Emergency Medicine·D C Stump, K G Mann
Oct 1, 1988·Stroke; a Journal of Cerebral Circulation·W HackeG J del Zoppo
Feb 1, 1988·Journal of Neurosurgery·J A ScottG J Becker
Mar 1, 1988·Stroke; a Journal of Cerebral Circulation·G J del ZoppoH Zeumer
Jul 1, 1988·Stroke; a Journal of Cerebral Circulation·E MoriA Yamadori
Mar 1, 1986·Stroke; a Journal of Cerebral Circulation·C R HornigA L Agnoli
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·G J Del ZoppoL A Harker
Jan 1, 1987·Stroke; a Journal of Cerebral Circulation·S BiedertR Reuther
Sep 1, 1987·Stroke; a Journal of Cerebral Circulation·I SaitoK Tsutsumi
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·R CôtéC Wolfson
Feb 1, 1974·Archives of Neurology·J S Karp, H I Hurtig
Jun 1, 1969·Journal of Neurology, Neurosurgery, and Psychiatry·C Fieschi, L Bozzao
Sep 1, 1969·The Journal of Clinical Investigation·M B Bernik, H C Kwaan
Nov 1, 1966·Archives of Neurology·W S FieldsR J Campos
Jan 1, 1984·Seminars in Thrombosis and Hemostasis·N Aoki, P C Harpel

❮ Previous
Next ❯

Citations

Mar 17, 2000·Current Opinion in Neurology·A Abou-Chebl, A J Furlan
Jul 1, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alex Abou-Chebl
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Rejane C LisboaMark J Alberts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.