Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review including GRADE assessments

The British Journal of Dermatology
E J van Zuuren, Zbys Fedorowicz

Abstract

Hirsutism is a common disorder with a major impact on quality of life. The most frequent cause is polycystic ovary syndrome. Effects of interventions (except laser and light-based therapies) were evaluated, including Grading of Recommendations Assessment, Development and Evaluation assessments. Searches included Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, Medline, Embase and five trials registers to June 2014. We included 157 randomized controlled trials (RCTs) with 10 550 participants. The majority were assessed as having a 'high risk' of bias (123 of 157). The quality of evidence was rated moderate to very low for most outcomes. Pooled data for an oral contraceptive (OCP) (ethinyl oestradiol and cyproterone acetate) compared with another OCP (ethinyl oestradiol and desogestrel) demonstrated that both treatments were effective in reducing Ferriman-Gallwey scores, but the mean difference (MD) was not statistically significant [-1·84, 95% confidence interval (CI): -3·86-0·18]. Flutamide was more effective than placebo in two studies (MD -7·60, 95% CI: -10·53 to -4·67 and MD -7·20, 95% CI: -10·15 to -4·25), as was spironolactone (MD -7·69, 95% CI: -10·12 to -5·26). Spironolactone appeared to be as e...Continue Reading

References

Jan 1, 1991·Acta Endocrinologica·S Akalin
May 1, 1991·The Journal of Clinical Endocrinology and Metabolism·R C O'BrienG Jerums
Jan 1, 1990·Acta Obstetricia Et Gynecologica Scandinavica·R ErkkolaS Aydinlik
Dec 1, 1989·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J PrezeljL Andolsek
Feb 1, 1989·Fertility and Sterility·A LissakH Abramovici
Jul 1, 1989·Postgraduate Medical Journal·A R McLellanG T McInnes
Aug 1, 1985·Acta Endocrinologica·I M HoldawayJ France
Oct 1, 1986·The Journal of Clinical Endocrinology and Metabolism·B CouzinetG Schaison
Aug 1, 1988·The Journal of Clinical Endocrinology and Metabolism·R S Rittmaster, M L Givner
Apr 1, 1987·British Journal of Obstetrics and Gynaecology·A P MurdochP Kendall Taylor
Jan 1, 1987·Gynecologic and Obstetric Investigation·J B SchmidtJ Spona
Aug 1, 1981·American Journal of Obstetrics and Gynecology·R HatchD Tredway
Jan 1, 1995·The Journal of Clinical Endocrinology and Metabolism·I L WongR A Lobo
Aug 1, 1993·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·G CreatsasD Aravantinos
Mar 1, 1993·Postgraduate Medical Journal·N SoninoM Boscaro
Apr 29, 1998·Cancer Chemotherapy and Pharmacology·S PiantadosiS Grossman
Jul 25, 1998·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·S VenturoliC Flamigni
Aug 12, 1998·Journal of Endocrinological Investigation·Y SahinI Müderris
Oct 16, 1999·Fertility and Sterility·A M PaolettiG B Melis
Oct 20, 1999·European Journal of Endocrinology·L FalsettiG Bugari
Mar 25, 2000·Fertility and Sterility·M TartagniV D'Addario
May 3, 2000·Clinical Endocrinology·P M SpritzerF Lhullier
May 20, 2000·Annals of the New York Academy of Sciences·G CreatsasG Mastorakos

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Citations

Aug 4, 2016·The British Journal of Dermatology·M Ohyama
Aug 29, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·E Makrantonaki, C C Zouboulis
Dec 24, 2018·Assay and Drug Development Technologies·Jukkarin SrivilaiKornkanok Ingkaninan
Dec 7, 2017·The Journal of Clinical Endocrinology and Metabolism·Costanzo MorettiAndrea Lenzi
Aug 7, 2019·Journal of the Endocrine Society·Selma Feldman WitchelAlexia S Peña
Sep 15, 2020·Clinical Endocrinology·Lachlan M AngusAda S Cheung
Nov 13, 2019·European Journal of Pharmacology·Sebastian StudentRafał Bułdak
Jan 26, 2020·General and Comparative Endocrinology·Julie Robitaille, Valerie S Langlois

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