Interventions for idiopathic steroid-resistant nephrotic syndrome in children

The Cochrane Database of Systematic Reviews
Elisabeth M HodsonJonathan C Craig

Abstract

The majority of children who present with their first episode of nephrotic syndrome, achieve remission with corticosteroid therapy. Children who fail to respond may be treated with immunosuppressive agents such as cyclophosphamide, chlorambucil or cyclosporin, or with non-immunosuppressive agents such as ACE inhibitors. Optimal combinations of these agents with the least toxicity remain to be determined. To evaluate the benefits and harms of interventions used to treat idiopathic steroid resistant nephrotic syndrome (SRNS) in children. Randomised controlled trials (RCTs) were identified from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, reference lists of articles and abstracts from conference proceedings. Date of most recent search: June 2005 RCTs and quasi-RCTs were included if they compared different immunosuppressive agents or non-immunosuppressive agents with placebo, prednisone or other agent given orally or parenterally in children aged three months to 18 years with SRNS. Two reviewers independently searched the literature, determined trial eligibility, assessed quality, extracted data and entered it in RevMan. For dichotomous outcomes, results were expressed as relative risk (RR) and 95%...Continue Reading

Citations

Mar 23, 2007·Archives of Disease in Childhood·Stephen D Marks
Mar 10, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Swati ChoudhryAmit Dinda
Feb 7, 2008·The Cochrane Database of Systematic Reviews·S C PalmerG F Strippoli
Sep 19, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Antonia PeñaMercedes Navarro
Mar 28, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabeth M Hodson, Jonathan C Craig
May 16, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christian PlankUNKNOWN Arbeitsgemeinschaft für Pädiatrische Nephrologie
Feb 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Scott E WenderferMichael C Braun
Feb 17, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sarah J SwartzDaniel I Feig
Oct 23, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ellen T McCarthyVirginia J Savin
Mar 13, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Djalila MekahliPierre Cochat
Jun 6, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michal MalinaTomas Seeman
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Elisabeth M HodsonJonathan C Craig
Nov 22, 2019·The Cochrane Database of Systematic Reviews·Isaac D LiuElisabeth M Hodson

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