Interventions for necrotizing soft tissue infections in adults.

The Cochrane Database of Systematic Reviews
Camille HuaLaurence Le Cleach

Abstract

Necrotizing soft tissue infections (NSTIs) are severe and rapidly spreading soft tissue infections of the subcutaneous tissue, fascia, or muscle, which are mostly caused by bacteria. Associated rates of mortality and morbidity are high, with the former estimated at around 23%, and disability, sequelae, and limb loss occurring in 15% of patients. Standard management includes intravenous empiric antimicrobial therapy, early surgical debridement of necrotic tissues, intensive care support, and adjuvant therapies such as intravenous immunoglobulin (IVIG). To assess the effects of medical and surgical treatments for necrotizing soft tissue infections (NSTIs) in adults in hospital settings. We searched the following databases up to April 2018: the Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE, Embase, and LILACS. We also searched five trials registers, pharmaceutical company trial results databases, and the US Food and Drug Administration and the European Medicines Agency websites. We checked the reference lists of included studies and reviews for further references to relevant randomised controlled trials (RCTs). RCTs conducted in hospital settings, that evaluated any medical or surgical treatment for adults with NSTI w...Continue Reading

References

Nov 30, 1989·The American Journal of Medicine·R J FassJ A Russell
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
May 1, 1995·Annals of Surgery·C R McHenryM A Malangoni
Aug 10, 2000·American Journal of Surgery·D ElliottR A Myers
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jessica DarenbergUNKNOWN StreptIg Study Group
Sep 17, 2004·Scandinavian Journal of Infectious Diseases·Sang-Ho ChoiNam Joong Kim
Dec 22, 2004·Archives of Surgery·David Wilkinson, David Doolette
Feb 23, 2005·Archives of Surgery·Daniel A AnayaEileen Bulger
Apr 9, 2005·BMJ : British Medical Journal·Saiidy HashamNick B Hart
Oct 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis L StevensUNKNOWN Infectious Diseases Society of America
Feb 24, 2006·Epidemiology and Infection·S M Ellis SimonsenJ L Lyon
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel A Anaya, E Patchen Dellinger
Apr 11, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·John P A Ioannidis, Thomas A Trikalinos
Jun 6, 2007·The Medical Journal of Australia·Kerry-Ann F O'GradyJonathan R Carapetis
Aug 19, 2007·Annals of Epidemiology·Ziyad B NuwayhidZuber D Mulla
Feb 12, 2008·Clinical and Experimental Dermatology·C SouyriUNKNOWN French Network of Pharmacovigilance Centres
Feb 15, 2008·The American Journal of Emergency Medicine·Cheng-Ting HsiaoI-Chuan Chen
Feb 20, 2008·Annals of Internal Medicine·Isabelle BoutronUNKNOWN CONSORT Group
Apr 29, 2008·Critical Care : the Official Journal of the Critical Care Forum·Anthony DelaneyUNKNOWN Protocolised Management In Sepsis (ProMISe) Investigators
May 9, 2008·Journal of Clinical Microbiology·Theresa L LamagniAftab Jasir
Jan 24, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Tam N PhamMatthew B Klein
Feb 21, 2009·Journal of the American College of Surgeons·Babak SaraniC William Schwab
Jul 25, 2009·PM & R : the Journal of Injury, Function, and Rehabilitation·Robert D Rondinelli
Oct 29, 2009·Surgical Infections·Addison K MayUNKNOWN Surgical Infection Society
Mar 10, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rebecca J McClaineJoseph S Solomkin
May 25, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Linda JohanssonAnna Norrby-Teglund
Aug 28, 2010·Critical Care Medicine·Ho H Phan, Christine S Cocanour
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Oct 7, 2011·Journal of Clinical Microbiology·A LepoutreUNKNOWN Microbiologists of the Epibac Network
Dec 18, 2013·The British Journal of Surgery·T GohC H Wong
May 3, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan R CarapetisRoss Andrews
Jun 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna LinnérAnna Norrby-Teglund

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Citations

Sep 16, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·C CharpentierUNKNOWN Henri Mondor Hospital Necrotizing Fasciitis Group
May 12, 2019·Infection·Norma Jung, Christian Eckmann
Jan 1, 2020·Hellēnikē cheirourgikē. Acta chirurgica Hellenica·Tarun KumarAshok Attri
Jun 3, 2021·Journal of Clinical Medicine·Gilbert DondersWerner Mendling

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