Interventions for paracetamol (acetaminophen) overdose.

The Cochrane Database of Systematic Reviews
Angela L ChiewNick A Buckley

Abstract

Paracetamol (acetaminophen) is the most widely used non-prescription analgesic in the world. Paracetamol is commonly taken in overdose either deliberately or unintentionally. In high-income countries, paracetamol toxicity is a common cause of acute liver injury. There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person. These interventions include inhibiting the absorption of paracetamol from the gastrointestinal tract (decontamination), removal of paracetamol from the vascular system, and antidotes to prevent the formation of, or to detoxify, metabolites. To assess the benefits and harms of interventions for paracetamol overdosage irrespective of the cause of the overdose. We searched The Cochrane Hepato-Biliary Group Controlled Trials Register (January 2017), CENTRAL (2016, Issue 11), MEDLINE (1946 to January 2017), Embase (1974 to January 2017), and Science Citation Index Expanded (1900 to January 2017). We also searched the World Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov database (US National Institute of Health) for any ongoing or completed trials (January 2017). We examined the reference lists of relevant papers identifie...Continue Reading

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Citations

Dec 20, 2018·The Cochrane Database of Systematic Reviews·Bert AvauEmmy De Buck
Dec 2, 2019·The Medical Journal of Australia·Angela L ChiewNicholas A Buckley
Nov 21, 2019·Mini Reviews in Medicinal Chemistry·Annalise R PfaffNuran Ercal
Aug 22, 2020·Curēus·Thor S SteadJose Rubero
Jul 21, 2020·World Journal of Hepatology·Laura Rotundo, Nikolaos Pyrsopoulos
Nov 24, 2020·Annals of Intensive Care·Bruno MégarbaneCharles Cerf
Dec 10, 2020·The Cochrane Database of Systematic Reviews·Jacky Tp SiuRicky D Turgeon
Oct 13, 2020·United European Gastroenterology Journal
Mar 20, 2021·Médecine sciences : M/S·Brendan Le DaréThomas Gicquel
Jul 14, 2021·Expert Opinion on Drug Safety·Miren García-CortésRaúl J Andrade
Aug 28, 2021·Medicina·Iwona PopiolekGrzegorz Porebski
Sep 18, 2021·BMC Pregnancy and Childbirth·Izabela MarzecMagdalena Durlik

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