Interventions for preventing silent cerebral infarcts in people with sickle cell disease.

The Cochrane Database of Systematic Reviews
Lise J EstcourtMiguel R Abboud

Abstract

Sickle cell disease (SCD) is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Silent cerebral infarcts are the commonest neurological complication in children and probably adults with SCD. Silent cerebral infarcts also affect academic performance, increase cognitive deficits and may lower intelligence quotient. To assess the effectiveness of interventions to reduce or prevent silent cerebral infarcts in people with SCD. We searched for relevant trials in the Cochrane Library, MEDLINE (from 1946), Embase (from 1974), the Transfusion Evidence Library (from 1980), and ongoing trial databases; all searches current to 19 September 2016. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register: 06 October 2016. Randomised controlled trials comparing interventions to prevent silent cerebral infarcts in people with SCD. There were no restrictions by outcomes examined, language or publication status. We used standard Cochrane methodological procedures. We included five trials (660 children or adolescents) published between 1...Continue Reading

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Citations

Aug 20, 2019·The Cochrane Database of Systematic Reviews·Magdalena Bofill RodriguezIain T Cameron
Mar 19, 2019·The Cochrane Database of Systematic Reviews·Emily LawTonya M Palermo
Apr 7, 2020·The Cochrane Database of Systematic Reviews·Lise J EstcourtMiguel R Abboud
Aug 2, 2018·The Cochrane Database of Systematic Reviews·Patricia M FortinLise J Estcourt

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