Interventions for subjective cognitive decline: systematic review and meta-analysis

BMJ Open
Rohan BhomeR J Howard

Abstract

This review provides a broad overview of the effectiveness of interventions for subjective cognitive decline (SCD) in improving psychological well-being, metacognition and objective cognitive performance. Databases including PubMed, Web of Science and Cochrane Systematic Reviews were searched up to August 2017 to identify randomised controlled trials evaluating interventions for SCD. Interventions were categorised as psychological, cognitive, lifestyle or pharmacological. Outcomes of interest included psychological well-being, metacognitive ability and objective cognitive performance. To assess the risk of bias, three authors independently rated study validity using criteria based on the Critical Appraisal Skills Programme. Random-effects meta-analyses were undertaken where three or more studies investigated similar interventions and reported comparable outcomes. Twenty studies met inclusion criteria and 16 had sufficient data for inclusion in the meta-analyses. Of these, only seven were rated as being high quality. Group psychological interventions significantly improved psychological well-being (g=0.40, 95% CI 0.03 to 0.76; p=0.03) but the improvement they conferred on metacognitive ability was not statistically significant (...Continue Reading

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Citations

Aug 8, 2019·Cognitive Neuropsychiatry·Rohan BhomeRobert J Howard
Apr 9, 2020·Neuropsychology Review·Hanna Malmberg GavelinAlex Bahar-Fuchs
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Oct 13, 2021·Alzheimer's Research & Therapy·Andrea Brioschi GuevaraGael Chételat

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