Interventions for the treatment of metastatic extradural spinal cord compression in adults.

The Cochrane Database of Systematic Reviews
Reena GeorgePrathap Tharyan

Abstract

Metastatic extradural spinal cord compression (MESCC) is treated with radiotherapy, corticosteroids, and surgery, but there is uncertainty regarding their comparative effects. This is an updated version of the original Cochrane review published in theCochrane Database of Systematic Reviews (Issue 4, 2008). To determine the efficacy and safety of radiotherapy, surgery and corticosteroids in MESCC. In March 2015, we updated previous searches (July 2008 and December 2013) of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, LILACS, CANCERLIT, clinical trials registries, conference proceedings, and references, without language restrictions. We also contacted experts for relevant published, unpublished and ongoing trials. Randomised controlled trials (RCTs) of radiotherapy, surgery and corticosteroids in adults with MESCC. Three authors independently screened and selected trials, assessed risk of bias, and extracted data. We sought clarifications from trial authors. Where possible, we pooled relative risks with their 95% confidence intervals, using a random effects model if heterogeneity was significant. We assessed overall evidence-quality using the GRADE approach. This update includes seven tri...Continue Reading

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