Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial

BMJ : British Medical Journal
Noah M IversJeremy M Grimshaw

Abstract

To test a scalable health system intervention to improve long term adherence to secondary prevention treatments among patients who have had a recent myocardial infarction. Three arm, pragmatic randomised controlled trial with blinded outcome assessment. Nine cardiac centres in Ontario, Canada. 2632 patients with obstructive coronary artery disease after a myocardial infarction, identified from a centralised cardiac registry. Participants were randomised 1:1:1 to receive usual care, five mail-outs developed through a user centred design process, or mail-outs plus phone calls. The phone calls were delivered first by an interactive automated system to screen for non-adherence to treatment. Trained lay health workers followed up as necessary. Interventions were coordinated centrally but delivered from each patient's hospital site. Co-primary outcomes were completion of cardiac rehabilitation and adherence to recommended medication. Data were collected by blinded assessors through patient report and from administrative health databases at 12 months. 2632 patients (mean age 66, 71% male) were randomised: 878 to the full intervention (mail plus phone calls), 878 to mail only, and 876 to usual care. Of the respondents, 174 (27%) of 643...Continue Reading

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Citations

Jan 20, 2021·BMJ : British Medical Journal·Luke WolfendenSze Lin Yoong
Dec 9, 2020·The Canadian Journal of Cardiology·Neville G SuskinRobert S McKelvie
Dec 17, 2020·Patient Preference and Adherence·Eleanna MakrisJustin M Wright
Aug 13, 2021·BMJ : British Medical Journal·Steven T SimonP Michael Ho
Dec 3, 2021·JAMA Network Open·Stephen B WiltonUNKNOWN Acute Myocardial Infarction Quality Assurance (AMIQA) Canada Investigators

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Methods Mentioned

BETA
coronary artery bypass

Clinical Trials Mentioned

NCT02382731

Software Mentioned

CorHealth
SAS
ISLAND

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