Interventricular Electrical Delay Is Predictive of Response to Cardiac Resynchronization Therapy.

JACC. Clinical Electrophysiology
Michael R GoldUlrika Birgersdotter-Green

Abstract

This study was conceived to evaluate the relationship between interventricular electrical delay, as measured by the right ventricle-left ventricle (RV-LV) interval, and outcomes in a prospectively designed substudy of the SMART-AV (SMARTDELAY determined AV Optimization) trial. Despite the well-documented benefit of cardiac resynchronization therapy (CRT), the nonresponder rate remains an important clinical problem. Implanting LV leads by traditional anatomic criteria has limited impact on outcomes. However, pacing at sites with late electrical activation improves CRT response rates. Thus, we hypothesized that interventricular electrical delay is associated with improved CRT outcomes. This was a multicenter study of patients with advanced heart failure undergoing CRT implantation. In 419 subjects, the unpaced RV-LV interval was measured in sinus rhythm. LV volumes and ejection fraction were measured by echocardiography at baseline and after 6 months of CRT by a blinded core laboratory. Quality of life (QOL) was assessed by a standardized questionnaire. When separated by quartiles based on interventricular delay, the magnitudes of LV volumes, ejection fraction and the QOL measure increased significantly with prolongation of RV-LV...Continue Reading

References

May 1, 1984·Circulation·J A VassalloM E Josephson
Mar 25, 1999·The American Journal of Cardiology·A AuricchioJ Spinelli
Mar 22, 2001·The New England Journal of Medicine·S CazeauUNKNOWN Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators
Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Nov 1, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jagmeet P SinghTheofanie Mela
Nov 29, 2008·Journal of the American College of Cardiology·Cecilia LindeUNKNOWN REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group
Mar 21, 2009·Journal of Cardiovascular Electrophysiology·Leslie A SaxonMichael R Bristow
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
Nov 10, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Biagio SassoneSerge S Barold
Jul 29, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giulio ZucchelliMaria Grazia Bongiorni
Feb 7, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hans Morten KristiansenSvein Faerestrand
Apr 24, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Frank Ruschitzka
Sep 4, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jean-Claude DaubertJose Luis Zamorano
Sep 13, 2012·Journal of Cardiovascular Electrophysiology·Jagdesh KandalaJagmeet P Singh
Mar 2, 2013·Journal of the American College of Cardiology·Laurence M EpsteinMelanie Maytin
Mar 19, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael R GoldKenneth A Ellenbogen
Jan 23, 2014·Journal of Cardiovascular Electrophysiology·Michael R GoldYinghong Yu

❮ Previous
Next ❯

Citations

Oct 17, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Finn AkerströmMiguel A Arias
Jul 31, 2018·Pacing and Clinical Electrophysiology : PACE·Michael R GoldKenneth A Ellenbogen
Dec 3, 2016·Circulation. Arrhythmia and Electrophysiology·Angelo Auricchio
Mar 7, 2019·Pacing and Clinical Electrophysiology : PACE·Jasmine Borg TahriNiels Risum
Feb 1, 2020·Journal of Cardiovascular Medicine·Francesco SolimeneAntonio D'Onofrio
Jun 21, 2020·Journal of Cardiovascular Electrophysiology·Ghassan MoubarakVirginie Ferchaud
Dec 7, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Daniele OddoneMichele Brignole
Jan 8, 2020·Journal of Cardiovascular Electrophysiology·Anaïs GautheyJean-Benoit le Polain de Waroux
Oct 26, 2018·Circulation. Arrhythmia and Electrophysiology·Michael R GoldKenneth A Ellenbogen
Jun 22, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·A SultanD Steven
Nov 27, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Simone PezzutoAngelo Auricchio
Mar 7, 2021·Heart Failure Clinics·Giuseppe PalmieroVincenzo Russo
Mar 29, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hye Bin GwagSeung-Jung Park
Mar 6, 2021·Pacing and Clinical Electrophysiology : PACE·Raffaele CorbisieroPedram Kazemain
Jul 11, 2021·Journal of Cardiovascular Electrophysiology·Scott M KoerberMichael R Gold

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.