Intestinal absorption and enterohepatic cycling of biliary iron originating from plasma non-transferrin-bound iron in rats

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Pierre BrissotA F Hofmann

Abstract

In iron overload, non-transferrin-bound iron (NTBI) is found in plasma and is rapidly removed by hepatocytes. Some of this NTBI is excreted into bile. Biliary excretion of NTBI, in the form of an iron-deferiprone chelate, is greatly increased by deferiprone, an iron chelator. The aim of this study was to test whether biliary iron as such or as an iron-deferiprone chelate (both originating from plasma NTBI) is absorbed from the intestine and re-secreted into bile. In healthy biliary fistula (donor) rats, biliary 55Fe originating from plasma NTBI was obtained by injecting Fe citrate (to saturate transferrin) followed by 55Fe. This biliary 55Fe was infused into the duodenum of (recipient) rats whose transferrin was saturated or unsaturated. Similar experiments were performed using iron-overloaded (donor) rats given deferiprone, followed by infusion of the biliary 55Fe-deferiprone chelate into iron-overloaded (recipient) rats. The results show that in healthy (recipient) rats, duodenal infusion of 55Fe from NTBI was followed by increased plasma 55Fe when transferrin was unsaturated, or by biliary excretion of 55Fe when transferrin was saturated, indicating intestinal absorption of 55Fe. In iron-overloaded rats, neither plasma nor b...Continue Reading

Citations

Jan 24, 2002·Journal of Hepatology·Mark HirshTheodore C Iancu
Jun 5, 2002·Journal of Hepatology·Olivier LoréalPierre Brissot
Jul 9, 1998·Free Radical Biology & Medicine·N Sreejayan, C von Ritter
Apr 15, 2014·Free Radical Biology & Medicine·Thomas D Coates
Aug 23, 2011·Biochimica Et Biophysica Acta·Pierre BrissotOlivier Loréal
Apr 6, 2018·Nature Reviews. Disease Primers·Pierre BrissotOlivier Loréal
Jun 10, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter KotankoNathan W Levin
Nov 30, 2018·Pharmaceuticals·Olivier LoréalPierre Brissot
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Johannes M RoobBrigitte M Winklhofer-Roob
May 30, 2021·The Journal of Biological Chemistry·Milankumar PrajapatiThomas B Bartnikas

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