PMID: 2113152Jan 1, 1990Paper

Intestinal absorption of arachidonic acid in experimental azotemia

Life Sciences
M V PahlN Patel

Abstract

The effect of renal failure (RF) on intestinal absorption of dietary fatty acids is not known. We studied the intestinal absorption of arachidonic acid (AA) in rats with experimental short-term (2 weeks post-subtotal nephrectomy) and long-term (5-6 weeks post-subtotal nephrectomy) RF. The results were compared with those obtained in sham-operated animals on liberal food intake (NL) and in those pair-fed (PF) with the respective RF groups. In vivo perfusion and in vitro incubation experiments were performed at a wide range of AA concentrations. The rates of AA transport determined both in vivo and in vitro were significantly lower in the short-term RF group than those found in the NL controls and the PF animals who showed comparable values. In contrast animals with long-term RF exhibited an increased rate of AA transport as compared with the respective controls. The observed changes in the transport rates appeared to parallel directional changes in mucosal mass which was reduced in animals with short-term RF and restored in those with long-term RF.

References

Apr 12, 1975·Lancet·J Zimmermann
Jan 1, 1978·Annual Review of Biochemistry·B SamuelssonC Malmsten
Jan 1, 1977·Nephron·B G DelanoT Manis
Feb 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·M V PahlF Oveisi
May 1, 1988·European Journal of Pediatrics·H W Seyberth, P G Kühl
Mar 1, 1983·The American Journal of Clinical Nutrition·N D VaziriL Dadufalza

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