Intestinal absorption of fluorescently labeled nanoparticles

Nanomedicine : Nanotechnology, Biology, and Medicine
Spomenka SimovicTejal A Desai

Abstract

Characterization of intestinal absorption of nanoparticles is critical in the design of noninvasive anticancer, protein-based, and gene nanoparticle-based therapeutics. Here we demonstrate a general approach for the characterization of the intestinal absorption of nanoparticles and for understanding the mechanisms active in their processing within healthy intestinal cells. It is generally accepted that the cellular processing represents a major drawback of current nanoparticle-based therapeutic systems. In particular, endolysosomal trafficking causes degradation of therapeutic molecules such as proteins, lipids, acid-sensitive anticancer drugs, and genes. To date, investigations into nanoparticle processing within intestinal cells have studied mass transport through Caco-2 cells or everted rat intestinal sac models. We developed an approach to visualize directly the mechanisms of nanoparticle processing within intestinal tissue. These results clearly identify a mechanism by which healthy intestinal cells process nanoparticles and point to the possible use of this approach in the design of noninvasive nanoparticle-based therapies. Advances in nanomedicine have resulted in the development of new therapies for various diseases. In...Continue Reading

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Citations

Jul 28, 2016·International Journal of Molecular Sciences·Wei LiuWeisan Pan
Feb 11, 2020·Current Protein & Peptide Science·Jiemin WangDaxiong Xiang
May 10, 2020·Nature Reviews. Cardiology·Sadeer G Al-KindiSanjay Rajagopalan
Jun 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Amrita BanerjeeSamir Mitragotri
Feb 23, 2020·International Journal of Pharmaceutics·Szu-Yuan WuRajendra Prasad N
Apr 24, 2020·Molecular Pharmaceutics·Pavithra NatarajanL Adriana Avila

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