Intestinal absorption of peptide enteral formulas in hypoproteinemic (volume expanded) rats: a paired analysis

Critical Care Medicine
R R BrinsonA E Taylor

Abstract

Previous studies have confirmed the improved tolerance of a peptide enteral compared to standard enteral alimentation in hypoalbuminemic, critically ill patients. Animal studies, including hypoproteinemic, volume-expanded rats, demonstrated that the protein hydrolysate of a peptide enteral formula was responsible for the enhanced absorption. The purpose of this study was to determine whether the composition of small MW peptides (protein hydrolysate) in two commercially available peptide enteral formulas would affect the rate of intestinal absorption and albumin clearance in intact jejunal loops before and during hypoproteinemia induced by iv infusion of Tyrode's solution in Sprague-Dawley rats. Net transmucosal water movement was calculated using a volume recovery method; albumin clearance was calculated using iv radiolabeled albumin. We studied three groups of animals during luminal perfusion with either Tyrode's solution, diet A containing 21% peptides, or diet B containing 56% peptides. When compared to luminal perfusion with Tyrode's solution (control animals), both diets significantly enhanced net transmucosal water absorption before volume expansion (p less than .05). With the induction of hypoproteinemia, diet B continue...Continue Reading

Citations

Aug 1, 1992·Digestive Diseases and Sciences·S A McClaveH L Snider
Dec 1, 1990·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·G P Zaloga
Dec 1, 1990·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R R Brinson
May 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·J BozaA Gil
Dec 1, 1989·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R R BrinsonW M Pitts
Jan 1, 1994·Annales Françaises D'anesthèsie Et De Rèanimation·C BadettiJ C Manelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.