PMID: 602250Dec 1, 1977Paper

Intestinal absorption of polymeric derivatives of the food dyes sunset yellow and tartrazine in rats

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
T HonohanT M Parkinson

Abstract

1. Absorption and metabolism of 14C-labelled sunset yellow (FD & C Yellow No. 6), tartrazine (FD & C Yellow No. 5) and high molecular weight polymeric derivatives of the two azo dyes were compared in rats. 2. A trace to 1.5 percent of unchanged monomeric dyes was excreted in urine and bile during the first 24 h after dosing. No unchanged dye was absorbed after administration of the polymeric derivatives. 3. In animals dosed with sunset yellow and its polymer derivative, absorption of the azo-bound cleavage product 1-amino-2-naphthol-6-sulphonic acid was 8.5 and 6.9 percent, respectively, while absorption of the cleavage product sulphanilic acid was 37.4 and 0 percent, respectively. 4. In animals dosed with tartrazine and its polymer derivative, absorption of the cleavage product aminopyrazolone and its metabolites was 4.0 and 4.6 percent, respectively. 5. Azo bond cleavage did not appear to be decreased in the polymer derivatives. However, the sulphanilic acid moiety of both dyes remained attached to the polymer backbone, resulting in a 95 percent decrease in sulphanilic acid absorption with polymeric tartrazine. 6. Decreased absorption of unchanged dyes and certain metabolites with the stable, non-absorbed polymeric derivative...Continue Reading

References

Jun 1, 1973·The British Journal of Dermatology·G Michaëlsson, L Juhlin
Aug 1, 1972·The Journal of Allergy and Clinical Immunology·L JuhlinO Zetterström
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Sep 1, 1962·Toxicology and Applied Pharmacology·J W DANIEL
Oct 1, 1964·Food and Cosmetics Toxicology·R JONESS E WRIGHT

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Citations

Nov 17, 1980·Life Sciences·J R GoldenringM H Teicher
Dec 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J C PhillipsI F Gaunt
Jan 1, 1985·Drug Metabolism Reviews·J P Brown, T M Parkinson
Oct 3, 2012·International Journal of Occupational and Environmental Health·Sarah Kobylewski, Michael F Jacobson
Aug 18, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Leire Pérez-IbarbiaUlrich S Schubert
Jan 11, 1992·Critical Reviews in Microbiology·K T ChungC E Cerniglia
May 1, 1981·Applied and Environmental Microbiology·J P Brown

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