Intestinal adaptation: structure, function, and regulation

Seminars in Pediatric Surgery
D P O'BrienB W Warner

Abstract

After massive small bowel resection (SBR), the remnant intestine undergoes an adaptive process characterized by increases in wet weight, protein and DNA content, villus height and crypt depth, and absorptive surface area. These changes are the result of a proliferative stimulus that increases crypt cell mitosis and augments cellular progression along the villus axis. Functionally, there is upregulation of the Na(+)/glucose cotransporter, Na(+)/H(+) exchanger, and other enzymes involved in intestinal digestion and absorption. These physiologic events are a compensatory response to the sudden loss of digestive and absorptive capacity by the remnant intestine. A major consequence of inadequate intestinal adaptation is lifelong dependence on parenteral nutrition, which results ultimately in cholestatic liver dysfunction. Furthermore, adaptation may be associated with changes in intestinal permeability and an increased risk of bacterial translocation and sepsis. Several mediators thought to be integral to the postresection adaptive response have been proposed, including luminal nutrients, gastrointestinal secretions, and humoral factors. A thorough understanding of intestinal adaptation will be essential in the rational development ...Continue Reading

References

Jun 29, 1978·The New England Journal of Medicine·R C Williamson
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Feb 1, 1992·Gastroenterology·J D SchulzkeE O Riecken
Jan 1, 1992·Archives of Surgery·A G KurkchubascheM I Rowe
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·S T O'DwyerD W Wilmore
Jan 18, 1989·Biochimica Et Biophysica Acta·S GrinsteinM J Mason
Mar 1, 1988·The American Journal of Clinical Nutrition·M J KorudaJ L Rombeau
May 15, 1983·Cancer·S Cohen
Jan 1, 1983·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S GutschmidtE O Riecken
Feb 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·E UrbanS C Whitney
Aug 1, 1994·Journal of Pediatric Surgery·M S ChaetB W Warner
Jul 1, 1994·The Journal of Surgical Research·O J HinesS W Ashley
Feb 1, 1994·Journal of Pediatric Surgery·K GeorgesonW Hardin
Apr 1, 1993·Archives of Surgery·J S ThompsonR F Harty
Feb 1, 1996·The Journal of Surgical Research·E E WhangS W Ashley
Jun 1, 1996·The Journal of Surgical Research·C D LiuD W McFadden
Mar 1, 1996·Journal of Pediatric Surgery·J CollinsD Kelly
Sep 1, 1996·Digestive Diseases and Sciences·J S ThompsonT E Adrian
May 1, 1997·Transplantation Proceedings·M GambararaM Castro
Apr 1, 1997·The Journal of Surgical Research·M A HelmrathB W Warner
Jul 1, 1997·The Journal of Surgical Research·B W WarnerC R Erwin
Jul 1, 1997·Digestive Diseases·J S ScolapioC R Fleming
Aug 12, 1998·The Journal of Surgical Research·M A HelmrathB W Warner
Oct 23, 1998·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·P AldazabalE Cuadrado
Dec 8, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·M A HelmrathB W Warner
Jun 17, 1999·Pediatric Surgery International·I EizaguirreJ A Tovar

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Citations

Sep 28, 2004·Pediatric Surgery International·Paul W Wales
May 27, 2005·Pediatric Surgery International·Igor SukhotnikEitan Shiloni
Nov 4, 2005·Pediatric Surgery International·Igor SukhotnikJorge G Mogilner
Nov 20, 2012·Pediatric Surgery International·Kuang Horng-Jamie KangTom Jaksic
Aug 24, 2006·Digestive Diseases and Sciences·D L SigaletA Zubaidi
Jan 24, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Vatche G AgopianMatthias Stelzner
Nov 2, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jennifer A LeinickeBrad W Warner
Dec 26, 2003·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Victoria A GardnerLorraine Chessell
Aug 2, 2003·Journal of Pediatric Surgery·Igor SukhotnikCarroll M Harmon
Oct 14, 2009·Journal of Gastroenterology and Hepatology·Julie E Bines
May 24, 2014·Journal of Pediatric Surgery·Ivan M GutierrezTom Jaksic
May 19, 2012·Journal of Pediatric Surgery·Carol OliveiraPaul W Wales
Jan 16, 2010·The Journal of Surgical Research·Karen E SpeckMichael A Helmrath
May 21, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·UNKNOWN Allied Health Sciences Section Ad Hoc Nutrition CommitteeJulie Parrott
Jan 22, 2008·Journal of Pediatric Surgery·Niramol TantemsapyaBrad W Warner
Nov 21, 2007·Journal of Pediatric Surgery·Paul W WalesAnnie Fecteau
Jun 15, 2007·Journal of Pediatric Surgery·Janice A TaylorBrad W Warner
May 4, 2005·Journal of Pediatric Surgery·Marcus D JarboeBrad W Warner
Jul 2, 2005·Journal of Pediatric Surgery·Nicole P BernalBrad W Warner
Mar 29, 2005·Journal of Pediatric Surgery·Igor SukhotnikMichael M Krausz
Feb 15, 2011·Expert Opinion on Therapeutic Targets·Pamela J Hornby, Beverley A Moore
Feb 14, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gary R MartinDavid L Sigalet
Sep 21, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Igor SukhotnikRon Shaoul
Dec 6, 2018·Nutrition Reviews·Maude Le GallJohanne Le Beyec
May 26, 2009·Journal of Pediatric Gastroenterology and Nutrition·Igor SukhotnikJorge G Mogilner
Dec 3, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wolfgang StehrBrad W Warner
Dec 16, 2005·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Jason J Cisler, Alan L Buchman
Sep 15, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christopher M DekaneyMichael A Helmrath
Oct 25, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Per T SangildDouglas Burrin
May 22, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Mirielle L PaulinePaul W Wales
Oct 17, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Siamak A Adibi
Jul 7, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·George ShengBrad W Warner

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