Intestinal adherent bacteria and bacterial translocation in breast-fed and formula-fed rats in relation to susceptibility to infection

Pediatric Research
Makiko NakayamaT Kuwata

Abstract

The barrier function of the intestinal mucosa is immature in the newborn mammal, and is strengthened by breast milk. We investigated this effect of breast milk by comparing the susceptibility to infection assessed in terms of adherent bacterial colonization of the intestinal tissue (AdC) and bacterial translocation (BT) between breast-fed and formula-fed newborn rats. Three-day-old rat pups were assigned to one of three groups: mother-reared (MR), pseudo-cannulated (sham), and artificially reared (AR). AR rats were infused with formula through an intragastric cannula, under the control of a computer-regulated pumping machine. MR and sham rat pups were reared with their respective dams and received breast milk until weaning in a specially designed cage. In 10-d-old rats, there was no significant difference in the fecal or cecal flora between the AR and MR groups, whereas the AdC and the BT to the liver were greater in the AR than MR group. Enterobacteriaceae, Streptococcus and/or Enterococcus, and Staphylococcus were dominantly detected as microorganisms in AdC flora and BT. The AdC flora did not directly reflect the bacterial colonization flora. These findings suggest that AR rat pups mature normally, although there is a greate...Continue Reading

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Citations

May 11, 2010·Nutrition Research Reviews·Isabelle Le Huërou-LuronGaëlle Boudry
Apr 29, 2009·World Journal of Gastroenterology : WJG·Jun LiuChuan-Yong Guo
Apr 10, 2010·Clinical & Developmental Immunology·Yi-Jun ZhouZhen-Juan He
Oct 12, 2007·Bioscience, Biotechnology, and Biochemistry·Masako YajimaTakaji Yajima
Apr 25, 2013·Seminars in Pediatric Surgery·Anatoly GrishinHenri R Ford
Nov 15, 2016·Bioscience, Biotechnology, and Biochemistry·Ryo InoueTakamitsu Tsukahara
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Jul 6, 2010·Journal of Pediatric Gastroenterology and Nutrition·Pascale Fança-BerthonCatherine Michel
Jun 12, 2009·Journal of Pediatric Gastroenterology and Nutrition·Els R Van HaverChrista J Van Ginneken
Jul 7, 2018·Frontiers in Cellular and Infection Microbiology·Juan C OssaMauricio J Farfán
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew D NealDavid J Hackam
Mar 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kathryn A KnoopRodney D Newberry

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