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Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

The Journal of Experimental Medicine

Apr 13, 2005

Christel RousseauxPierre Desreumaux

Abstract

5-aminosalicylic acid (5-ASA) is an antiinflammatory drug widely used in the treatment of inflammatory bowel diseases. It is known to inhibit the production of cytokines and inflammatory mediators, but the mechanism underlying the intestinal effects of 5-ASA remains unknown. Based on th...read more

Mentioned in this Paper

Taenia Coli
Organ Culture Techniques
Squamous Transitional Epithelial Cell Count
Anti-Inflammatory Agents
PPARG gene
Cell Nucleus
Colitis
Peroxisome Biogenesis Pathway
Mesalamine
Cytokine
136
Paper Details
References
  • References45
  • Citations188
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  • References45
  • Citations188
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Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

The Journal of Experimental Medicine

Apr 13, 2005

Christel RousseauxPierre Desreumaux

PMID: 15824083

DOI: 10.1084/jem.20041948

Abstract

5-aminosalicylic acid (5-ASA) is an antiinflammatory drug widely used in the treatment of inflammatory bowel diseases. It is known to inhibit the production of cytokines and inflammatory mediators, but the mechanism underlying the intestinal effects of 5-ASA remains unknown. Based on th...read more

Mentioned in this Paper

Taenia Coli
Organ Culture Techniques
Squamous Transitional Epithelial Cell Count
Anti-Inflammatory Agents
PPARG gene
Cell Nucleus
Colitis
Peroxisome Biogenesis Pathway
Mesalamine
Cytokine
136

Feeds With Similar Papers

Nuclear Envelope Dynamics

The nuclear envelope provides barrier between the nucleus and cytoplasm. It plays a key role in transport function and nuclear growth, organization, and integrity. Discover the latest research on nuclear envelope dynamics here.

Inflammatory Bowel Disease

Inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis, arise due to chronic inflammation of the gastrointestinal tract. Here is the latest research.

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Paper Details
References
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  • References45
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