Intestinal archaea inversely associated with childhood asthma

The Journal of Allergy and Clinical Immunology
David J M BarnettC Thijs

Abstract

Methanogenic archaea are a key part of the gut microbiota alongside bacteria. However there is comparatively little research on the role of archaea in health. As in-vitro and animal experiments have demonstrated immunological effects of archaea, we hypothesised that intestinal exposure to archaeal species would influence the risk of asthma and other allergic diseases. We present the first human study connecting gut archaea with childhood asthma. We performed a cross-sectional analysis nested within the Dutch KOALA Birth Cohort Study. DNA from two common intestinal archaeal species, Methanosphaera stadtmanae and Methanobrevibacter smithii, was quantified in faecal samples from 472 children at school age, using qPCR. Our primary outcome was parent-reported asthma at 6-10 years. Secondary outcomes were questionnaire-reported eczema, total serum IgE levels, sensitisation to aero- and food-allergens and lung function (FEV1/FVC). Associations between the presence/absence of each archaeal species and outcome were assessed with logistic or linear regression models, adjusted for potential confounders. Presence of M. stadtmanae was significantly associated with a lower risk of asthma, adjusted OR 0.32 (0.08 - 0.98). In addition, asthma r...Continue Reading

Citations

Oct 1, 2019·Current Opinion in Pulmonary Medicine·Ariangela Kozik, Yvonne J Huang
Sep 16, 2019·Clinical Reviews in Allergy & Immunology·Youssouf SeremeJoana Vitte
Jul 22, 2020·Nature Reviews. Microbiology·Guillaume BorrelChristine Moissl-Eichinger
Feb 23, 2020·Immunity·Weronika BarcikB Brett Finlay
Aug 2, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Jan K NowakJarosław Walkowiak

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