Intestinal barrier dysfunction in severe burn injury

Burns and Trauma
Wen HeFengjun Wang

Abstract

Severe burn injury is often accompanied by intestinal barrier dysfunction, which is closely associated with post-burn shock, bacterial translocation, systemic inflammatory response syndrome, hypercatabolism, sepsis, multiple organ dysfunction syndrome, and other complications. The intestinal epithelium forms a physical barrier that separates the intestinal lumen from the internal milieu, in which the tight junction plays a principal role. It has been well documented that after severe burn injury, many factors such as stress, ischemia/hypoxia, proinflammatory cytokines, and endotoxins can induce intestinal barrier dysfunction via multiple signaling pathways. Recent advances have provided new insights into the mechanisms and the therapeutic strategies of intestinal epithelial barrier dysfunction associated with severe burn injury. In this review, we will describe the current knowledge of the mechanisms involved in intestinal barrier dysfunction in response to severe burn injury and the emerging therapies for treating intestinal barrier dysfunction following severe burn injury.

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Citations

Sep 26, 2020·Scientific Reports·Wayne T MuraokaDavid M Burmeister
Jul 1, 2020·Frontiers in Bioengineering and Biotechnology·Yuzhen WangJun Wu
Sep 29, 2020·Frontiers in Physiology·Huapei SongFengjun Wang
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Jul 24, 2021·Cell Biochemistry and Biophysics·Zhensen ZhuXiongxiang Zhu
Jan 23, 2021·Shock·Marisa E LuckMashkoor A Choudhry

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Methods Mentioned

BETA
gene knockout

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