Intestinal Barrier Interactions with Specialized CD8 T Cells

Frontiers in Immunology
Špela KonjarMarc Veldhoen

Abstract

The trillions of microorganisms that reside in the gastrointestinal tract, essential for nutrient absorption, are kept under control by a single cell barrier and large amounts of immune cells. Intestinal epithelial cells (IECs) are critical in establishing an environment supporting microbial colonization and immunological tolerance. A large population of CD8(+) T cells is in direct and constant contact with the IECs and the intraepithelial lymphocytes (IELs). Due to their location, at the interphase of the intestinal lumen and external environment and the host tissues, they seem ideally positioned to balance immune tolerance and protection to preserve the fragile intestinal barrier from invasion as well as immunopathology. IELs are a heterogeneous population, with a large innate-like contribution of unknown specificity, intercalated with antigen-specific tissue-resident memory T cells. In this review, we provide a comprehensive overview of IEL physiology and how they interact with the IECs and contribute to immune surveillance to preserve intestinal homeostasis and host-microbial relationships.

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Citations

Apr 21, 2018·Annual Review of Immunology·Holm H Uhlig, Fiona Powrie
Jul 26, 2018·European Journal of Immunology·Marc VeldhoenCristina Ferreira
Apr 3, 2020·Journal of Crohn's & Colitis·Christopher J TylerJesús Rivera-Nieves
Aug 6, 2019·Frontiers in Immunology·Špela Konjar, Marc Veldhoen
Nov 30, 2019·Tissue Barriers·Jacob C McCright, Katharina Maisel
Nov 26, 2019·The Journal of Clinical Investigation·Paul OgongoSamuel M Behar
Jun 24, 2018·Science Immunology·Špela KonjarMarc Veldhoen
Apr 7, 2019·Mucosal Immunology·Mei Lan ChenMark S Sundrud
May 20, 2020·Nature Immunology·Cristina FerreiraMarc Veldhoen
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
Dec 6, 2018·Cell Proliferation·Jiuheng YinHua Yang
Jun 3, 2021·International Journal of Molecular Sciences·Karin EnderleClemens Neufert
Oct 6, 2021·Mucosal Immunology·Leandro BarrosMarc Veldhoen

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Methods Mentioned

BETA
IECs
IEC
flow cytometry

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