Intestinal Behcet's disease with pyoderma gangrenosum: a case report

World Journal of Gastroenterology : WJG
Toshio NakamuraHiroyuki Konno

Abstract

We report here a very rare case of intestinal Behcet's disease with pyoderma gangrenosum. A 16-year-old woman who was diagnosed with intestinal Behcet's disease by the presence of cutaneous pathergy together with two major criteria (oral and genital aphthoses) and one minor criterion (gastrointestinal manifestations), was referred to our hospital with a left lower leg ulcer and abdominal pain in September 1989. Colonoscopy demonstrated flare-up colitis involving the entire colon. Her lower leg lesion was a painful destructive ulcer with an irregular margin and a ragged overhanging edge. Based on these clinical and laboratory findings, we diagnosed her cutaneous ulcer as pyoderma gangrenosum developing with exacerbated intestinal Behcet's disease. Her cutaneous and intestinal lesions were poorly controlled though she received oral prednisolone treatment for a month. Because of aggravated abdominal symptoms with peritoneal irritation, we performed total colectomy in November 1989. The resected specimen was histologically compatible with intestinal Behcet's disease showing severe inflammation with deep ulcerations and neutrophil accumulation. Subsequently, pyoderma gangrenosum rapidly improved. This clinical course may suggest the...Continue Reading

References

Jun 1, 1979·Annals of the Rheumatic Diseases·D W JamesM J Smith
Jun 1, 1991·The British Journal of Surgery·M D LevittR K Phillips
Nov 1, 1990·Journal of the American Academy of Dermatology·M H RustinT W Robinson
Apr 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R J LilfordA G Batchelor
Jan 1, 1997·International Reviews of Immunology·N MizukiS Ohno
Mar 26, 1998·Seminars in Arthritis and Rheumatism·V G KaklamaniP G Kaklamanis

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Citations

Sep 16, 2010·Clinical Rheumatology·Iliana AlexoudiGeorge Vaiopoulos
Sep 21, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Anthony Baldea, Richard L Gamelli
Jul 3, 2008·Digestive Diseases and Sciences·Ellen C Ebert
Jun 1, 2009·The Indian Journal of Surgery·Abhijit D HiregoudarU S Dinesh

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