Intestinal calcium transport and its regulation in thalassemia: interaction between calcium and iron metabolism

The Journal of Physiological Sciences : JPS
Kornkamon LertsuwanNarattaphol Charoenphandhu

Abstract

Osteoporosis and derangement of calcium homeostasis are common complications of thalassemia. Despite being an important process for bone and calcium metabolism, little is known about intestinal calcium transport in thalassemia. Recent reports of decreases in both intestinal calcium transport and bone mineral density in thalassemic patients and animal models suggested that defective calcium absorption might be a cause of thalassemic bone disorder. Herein, the possible mechanisms associated with intestinal calcium malabsorption in thalassemia are discussed. This includes alterations in the calcium transporters and hormonal controls of the transcellular and paracellular intestinal transport systems in thalassemia. In addition, the effects of iron overload on intestinal calcium absorption, and the reciprocal interaction between iron and calcium transport in thalassemia are elaborated. Understanding the mechanisms underlining calcium malabsorption in thalassemia would lead to development of therapeutic agents and mineral supplements that restore calcium absorption as well as prevent osteoporosis in thalassemic patients.

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Citations

Dec 21, 2018·The Journal of Physiological Sciences : JPS·Ei Ei MonKazuhito Tomizawa
Jun 22, 2019·The Journal of Physiological Sciences : JPS·Kannikar WongdeeNarattaphol Charoenphandhu
Aug 1, 2019·Current Drug Targets·Eman M HamedRaghda R S Hussein
Jul 14, 2020·World Journal of Gastroenterology : WJG·Vanessa A ArecoMaría E Peralta López
Oct 29, 2020·Biological Trace Element Research·Joanna SuliburskaAgata Chmurzyńska
Jan 26, 2021·Nutrition Reviews·Natalia Wawrzyniak, Joanna Suliburska
Feb 6, 2021·International Journal of Environmental Research and Public Health·Joanna SuliburskaDanuta Baralkiewicz
Jan 11, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P P ManolopoulosE O Johnson
Jun 8, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Yuhua LeiYan-Zhong Chang
Oct 14, 2021·PloS One·Supathra PhoaubonNarattaphol Charoenphandhu

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