PMID: 517652Dec 1, 1979Paper

Intestinal capillary blood flow during metabolic hyperemia

The American Journal of Physiology
A P Shepherd

Abstract

It has been postulated that local circulatory control mechanisms regulate the O2 flux to parenchymal cells by two vascular mechanisms: changes in blood flow that minimize capillary PO2 variations and changes in the density of the perfused capillary bed through which O2 extraction is regulated. To test this prediction, isolated loops of canine jejenum and ileum were perfused at either constant blood flow or constant pressure, and intraluminal glucose was used to increase metabolic rate. In the constant-flow series, glucose increased O2 extraction, O2 uptake, and rubidium extraction. Resistance fell when the metabolic rate was elevated. In the constant-pressure series, glucose increased blood flow, O2 extraction, O2 uptake, and capillary filtration coefficients. These results show that vascular resistance falls and that capillary density increases following an increase in oxygen demand. Thus, the glucose-stimulated gut loop seems to be a valid model of metabolic hyperemia, and its behavior would be difficult to reconcile with a purely myogenic theory of intestinal blood flow autoregulation.

References

Sep 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·P R KvietysC C Chou
Feb 1, 1976·The American Journal of Physiology·A P ShepherdE D Jacobson
Mar 1, 1976·The American Journal of Physiology·C C ChouJ M Dabney
May 1, 1974·Journal of Applied Physiology·S F VatnerD Franklin
Oct 3, 1969·Science·J W FaraR R Sonnenschein
Nov 1, 1972·The American Journal of Physiology·J W FaraR R Sonnenschein
Jan 1, 1973·Microvascular Research·H J Granger, A P Shepherd
Apr 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·A Wollin, L B Jaques
Jul 11, 1968·The American Journal of Physiology·P D Van HeerdenS Kaihara
Oct 1, 1966·Circulation Research·P C Johnson, K M Hanson
Jan 1, 1967·The American Journal of Digestive Diseases·V VarróG Blahó

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Citations

Dec 5, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Henrik SethMichael Axelsson

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