PMID: 6984435Dec 1, 1982Paper

Intestinal cell radiosensitivity: a comparison for cell death assayed by apoptosis or by a loss of clonogenicity

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
J H Hendry, C S Potten

Abstract

Apoptotic and reproductive cell death have been assayed in the crypt of the small intestine. These two approaches result in survival curves with mean lethal doses (D0) that differ by a factor of 10. Widely differing doses and times of assay post-irradiation were used for the assays employing apoptosis in one case and clonogenicity in the other. The results obtained by the two approaches are compared. It is concluded that the cells that die via apoptosis represent a very sensitive subpopulation of the crypt (about 6 cells per crypt) that may or may not be clonogenic. Most clonogenic cells die at a later time by some other mechanism. If the apoptoses represent dead clonogenic cells they must be either a very sensitive subpopulation or, as deduced here, a subpopulation which is part of a uniformly resistant population of cells when clonogenicity is considered, but which is very sensitive to an early form of death.

References

Sep 1, 1970·Radiology·E L GilletteI F Tannock
Nov 1, 1981·International Journal of Radiation Oncology, Biology, Physics·H D ThamesB O Reid

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Citations

Aug 1, 1992·Biological Reviews of the Cambridge Philosophical Society·S Sen
Jan 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J H Hendry
May 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·K Ijiri, C S Potten
Dec 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J H HendryM Bianchi
Nov 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·K Ijiri, C S Potten
Dec 1, 1990·International Journal of Radiation Biology·C S Potten
May 1, 1997·International Journal of Radiation Biology·K R BlankW G McKenna
Dec 7, 2007·International Journal of Radiation Biology·Iris EkeNils Cordes
Apr 1, 1991·International Journal of Radiation Biology·S J Martin, T G Cotter
Mar 1, 1984·International Journal of Cell Cloning·C S PottenW R Hanson
Mar 1, 1983·British Journal of Haematology·J H Winter, B Bennett
Jan 5, 2002·Australasian Physical & Engineering Sciences in Medicine·L JonesP Metcalfe
Mar 1, 1995·Radiation and Environmental Biophysics·J H HendryA Merritt
Dec 12, 2012·Investigational New Drugs·Ya-Jen ChangTe-Wei Lee
Dec 1, 1984·Diseases of the Colon and Rectum·H C UmplebyR C Williamson
Feb 1, 1984·The British Journal of Surgery·J B BristolR C Williamson
Mar 1, 1984·The British Journal of Surgery·J B RaineyR C Williamson
Jan 26, 2008·Journal of Radiation Research·Masatoshi Suzuki, David A Boothman
Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·A MaityW G McKenna
Oct 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A V D'Amico, W G McKenna

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