Intestinal challenge with enterotoxigenic Escherichia coli in pigs, and nutritional intervention to prevent postweaning diarrhea

Animal Nutrition
Yawang Sun, Sung Woo Kim

Abstract

Gut health of nursery pigs immediately after weaning is tightly associated with their growth performance and economic values. Postweaning diarrhea (PWD) is one of the major concerns related to gut health of nursery pigs which often is caused by infections of enterotoxigenic Escherichia coli (ETEC), mainly including F4 (K88)+ and F18+E. coli. The main virulence factors of ETEC are adhesins (fimbriae or pili) and enterotoxins. The common types of fimbriae on ETEC from PWD pigs are F18+ and F4+. Typically, PWD in pigs is associated with both F18+ and F4+ ETEC infections whereas pre-weaning diarrhea in pigs is associated with F4+ ETEC infection. Enterotoxins including heat-labile enterotoxins (LT) and heat-stable peptide toxins (ST) are associated with causing diarrhea in pigs. At least 109 to 1010 ETEC are required to induce diarrhea in nursery pigs typically lasting 1 to 5 days after ETEC infection. Antibiotics used to be the most effective way to prevent PWD, however, with the increased bacterial resistance to antibiotics, alternatives to the use of antibiotics are urgently needed to prevent PWD. Immunopropylaxis and nutritional intervention of antimicrobial minerals (such as zinc oxide and copper sulfate), organic acids, functi...Continue Reading

Citations

Sep 3, 2019·Animal : an International Journal of Animal Bioscience·B HumphreyR Faris
Sep 5, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Francesca Romana MassacciChiara Francesca Magistrali
Sep 5, 2020·Microbiology Resource Announcements·Alice FerreiraAna Oliveira
Oct 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weiwei WangHuili Pang
Mar 12, 2021·Animal Bioscience·Sung Woo Kim, Marcos E Duarte
Apr 20, 2021·Frontiers in Veterinary Science·Rajesh Jha, Sung Woo Kim
Nov 15, 2019·Current Protein & Peptide Science·Xiao-Pei PengYun-Fu Li
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Anlly Fresno RuedaBenoit St-Pierre
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Luciana RossiAntonella Baldi

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Methods Mentioned

BETA
ELISA
PCR

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