Intestinal colonization with Candida albicans and mucosal immunity

World Journal of Gastroenterology : WJG
Xiao-Dong BaiQing-Ying Tong

Abstract

To observe the relationship between intestinal lumen colonization with Candida albicans and mucosal secretory IgA (sIgA). A total of 82 specific-pathogen-free mice were divided randomly into control and colonization groups. After Candida albicans were inoculated into specific-pathogen-free mice, the number of Candida albicans adhering to cecum and mucosal membrane was counted. The lymphocyte proliferation in Peyer's patch and in lamina propria was shown by BrdU incorporation, while mucosal sIgA (surface membrane) isotype switch in Peyer's patch was investigated. IgA plasma cells in lamina propria were observed by immunohistochemical staining. Specific IgA antibodies to Candida albicans were measured with ELISA. From d 3 to d 14 after Candida albicans gavaging to mice, the number of Candida albicans colonizing in lumen and adhering to mucosal membrane was sharply reduced. Candida albicans translocation to mesenteric lymph nodes occurred at early time points following gavage administration and disappeared at later time points. Meanwhile, the content of specific IgA was increased obviously. Proliferation and differentiation of lymphocytes in lamina propria were also increased. Lymphocytes in lamina propria play an important role i...Continue Reading

References

Jan 1, 1997·Annual Review of Microbiology·M E Lamm
May 17, 2002·International Journal of STD & AIDS·M BelaziD Panayiotidou
Sep 14, 2002·Infection and Immunity·Karen L WozniakPaul L Fidel
Nov 20, 2002·World Journal of Gastroenterology : WJG·Jian-Min RenWen-Kun Zen
Feb 11, 2004·Clinical & Developmental Immunology·Douglas L SchmuckerKarine Thoreux

❮ Previous
Next ❯

Citations

Apr 3, 2013·Microbiological Research·Lei YanJianguo Tang
Apr 13, 2018·Pathogens and Disease·Jack GuinanShankar Thangamani
Nov 6, 2020·Nature·Zachary FitzpatrickMenna R Clatworthy
Jul 16, 2021·Nature·Kyla S OstJune L Round

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

Medicine and Science in Sports and Exercise
Kazuhiro ShimizuIchiro Kono
Advances in Experimental Medicine and Biology
C Vincent, J P Revillard
Journal of the Indian Society of Pedodontics and Preventive Dentistry
E RanadheerV Arun Prasad Rao
© 2022 Meta ULC. All rights reserved