Intestinal colonization with Clostridium difficile in infants up to 18 months of age

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
K TullusR Möllby

Abstract

The faecal colonization with Clostridium difficile was investigated among 343 infants during their first 18 months of life. Rectal swabs were taken at the ages of 6 days, 6 weeks, 6 months, 11 months and 18 months. About 25% of the children were colonized with Clostridium difficile between 6 days and 6 months of age. The colonization rate decreased to 3% at 18 months of age. The rate of strains producing cytotoxin was low in infants less than 6 months of age, but at that age about half of the strains isolated were toxin-producing. Breast-fed children were significantly less often colonized with Clostridium difficile than were bottle-fed infants, both at 6 weeks of age (21% versus 47%, p less than 0.05) and at 6 months of age (19% versus 39%, p less than 0.001). Colonization with Clostridium difficile at 6 months of age was associated with a greater frequency of diarrhoeal disease between 6 and 11 months of age (27% versus 16%, p less than 0.05). This association was even more pronounced when the bacteria persisted at 11 months of age (54%, p less than 0.01). Antibiotic therapy could not be demonstrated to influence colonization with Clostridium difficile at any age.

References

Feb 1, 1979·Journal of Clinical Microbiology·W L GeorgeS M Finegold
May 1, 1988·Archives of Disease in Childhood·E H PriceS Tabaqchali
Jun 1, 1986·Journal of Medical Microbiology·S P Borriello, F E Barclay
Jan 1, 1968·Acta Pathologica Et Microbiologica Scandinavica·B GästrinA Marcetic
Sep 24, 1983·British Medical Journal·S A RichardsonJ Gray
Mar 1, 1983·American Journal of Diseases of Children·J L SutphenJ G Bartlett
May 1, 1983·Journal of Clinical Microbiology·M CooperstockA Onderdonk
Dec 1, 1982·The Journal of Infectious Diseases·H E LarsonI D Hill
Sep 1, 1982·Pediatric Infectious Disease·D A BoenningR W Quinlan
Jan 1, 1981·Scandinavian Journal of Infectious Diseases·E HolstP A Mårdh
Jan 1, 1981·Medical Microbiology and Immunology·B AronssonC E Nord

❮ Previous
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Citations

Apr 1, 1993·European Journal of Pediatrics·A CollignonG Corthier
Jul 5, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I H M FriesemaY T H P van Duynhoven
Sep 21, 2000·Journal of Pediatric Gastroenterology and Nutrition·L V McFarlandS Guandalini
Jun 1, 1996·The Pediatric Infectious Disease Journal·D K MitchellL K Pickering
Jan 6, 2006·The Pediatric Infectious Disease Journal·Louis VernacchioDavid W K Acheson
Jan 15, 2011·The Pediatric Infectious Disease Journal·Thomas J SandoraGrace M Lee
Aug 1, 1993·Archives of Disease in Childhood·S P HardyL Spitz
Mar 1, 2014·Journal of the Pediatric Infectious Diseases Society·Julia Shaklee SammonsAdam L Hersh
Jul 15, 2015·Journal of Gastroenterology·Rowena AlmeidaElaine O Petrof
Jan 3, 2013·Journal of Travel Medicine·Ami NeubergerEli Schwartz
Mar 12, 2011·Journal of Medical Microbiology·Clotilde RousseauAnne Collignon
Apr 25, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E A LeesE D Carrol
Sep 13, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Basu
Oct 9, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Erik R DubberkeDeborah S Yokoe
Jan 15, 2015·Infectious Disease Clinics of North America·Dale N Gerding, Fernanda C Lessa
Feb 22, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Maribeth R NicholsonThomas R Talbot
Jun 26, 2017·The Journal of Infection·Becky ChenSimon Dobson
Feb 21, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L Clifford McDonaldMark H Wilcox
Apr 29, 2015·Expert Review of Gastroenterology & Hepatology·Susanna EspositoNicola Principi
Nov 1, 2013·Journal of Clinical Microbiology·Ingegerd AdlerberthAndrej Weintraub
Jun 26, 2013·Antimicrobial Agents and Chemotherapy·Hayden T SchwenkThomas J Sandora
Jul 28, 2016·Applied and Environmental Microbiology·Hiroyuki KubotaKenji Oishi
Jan 16, 2009·Acta Paediatrica·I Adlerberth, A E Wold
Jan 29, 2009·The Pediatric Infectious Disease Journal·Kristina Bryant, L Clifford McDonald
Jun 1, 2010·Journal of Pediatric Gastroenterology and Nutrition·Sushrut Jangi, J Thomas Lamont
May 23, 2014·Expert Review of Anti-infective Therapy·Alison L GaldysLee H Harrison
Jul 24, 2003·Equine Veterinary Journal·V BåverudA Gunnarsson
Jan 1, 2014·Children·Maribeth R NicholsonKathryn M Edwards
Aug 9, 2016·Current Problems in Surgery·Monika A KrezalekJohn C Alverdy
Nov 3, 2004·The Veterinary Clinics of North America. Equine Practice·Viveca Båverud
Mar 13, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S ReddyI R Poxton
Oct 10, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B SvenungssonA Lundberg
Jun 13, 2021·Hospital Pediatrics·Masrur A Khan, Fatuma Barqadle
Aug 3, 2006·Pediatrics·John PendersEllen E Stobberingh

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