PMID: 6139431Oct 1, 1983Paper

Intestinal contribution to the presystemic elimination of beta-phenethylamine in the rat

The Journal of Pharmacy and Pharmacology
P J Worland, K F Ilett

Abstract

The metabolism of beta-phenethylamine (PEA) has been investigated in intestinal, liver and lung homogenates from the rat. Metabolic activity was ranked liver much greater than lung much greater than duodenum greater than jejunum greater than ileum greater than colon. Absorption and metabolism of PEA was also studied using in-situ intestinal loops from rats. Absorption of PEA appeared to be a passively mediated process with metabolism occurring in jejunum, ileum and colon. When isolated loops of jejunum were used, phenylacetic acid was the only metabolite formed. Presystemic elimination of PEA in anaesthetized rats, was largely attributable to the intestine and lung with a relatively small hepatic contribution.

References

Jan 1, 1979·British Journal of Pharmacology·Y S Bakhle, M B Youdim
Apr 1, 1976·British Journal of Clinical Pharmacology·I E HughesK F Ilett
Jan 1, 1975·Canadian Journal of Biochemistry·P H Wu, A A Boulton
Sep 18, 1975·Nature·J W SchweitzerR Schwartz
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Oct 1, 1968·Journal of Pharmaceutical Sciences·W H Hong, K A Connors
Jan 1, 1980·The Journal of Pharmacy and Pharmacology·M K Cassidy, J B Houston
Feb 15, 1980·Biochemical Pharmacology·R R Ben-Harari, Y S Bakhle
Aug 1, 1960·Journal of Medicinal and Pharmaceutical Chemistry·L S SCHANKER

Citations

Jan 1, 1990·Pharmacology & Therapeutics·K F IlettR F Minchin
Jul 16, 2009·Drug Metabolism Reviews·Alan BoobisKeith Tipton
Apr 11, 2018·Journal of Neural Transmission·Keith F Tipton

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