Intestinal damage in gastroschisis is independent of the size of the abdominal defect

Pediatric Surgery International
A AlbertL Morales

Abstract

The intestinal damage in gastroschisis (GS) has been attributed to a narrow abdominal wall defect (AWD), among other causes, but this causal effect is difficult to prove in humans. The present experimental study was done to ascertain the damaging effect of clinically extrapolable mild and moderate constriction at the AWD on the intestine of fetuses with GS. AWDs of two different sizes were carried out in the fetal rabbit model: small-ring GS (1.5x bowel diameter, SRG) and large-ring GS (3x bowel diameter, LRG); a group of unoperated littermates served as controls. Fetal body weight, intestinal length and weight, bowel diameter and wall thickness, and histology were checked 7 days later. No statistical difference was found in body weight and bowel diameter among the groups. Intestinal length, weight, and wall thickness were significantly different in the GS groups compared to the controls, but no difference was found between the GS groups. Histology did not show venous stasis, ischemic lesions, or differences in the degree of edema between groups SRG and LRG. Mesothelial hyperplasia was seen in both GS groups. The intestinal changes in length, weight, diameter, wall thickness, and histology in GS should thus not be attributed to...Continue Reading

Citations

Mar 12, 2009·Pediatric Surgery International·Ryan P DavisGeorge B Mychaliska
Feb 15, 2012·Pediatric Surgery International·Arash SafaviSonia Butterworth
Aug 2, 2003·Journal of Pediatric Surgery·Asteria AlbertLuis Morales
Oct 18, 2002·Obstetrics and Gynecology·Jasmine HuangFrancois L Luks
Jul 20, 2002·Current Opinion in Pediatrics·Thomas R WeberSteven J Fishman
Oct 16, 2007·Fetal Diagnosis and Therapy·Willy Marcus FrançaLourenço Sbragia
Nov 11, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Frances Lilian Lanhellas GonçalvesLourenço Sbragia
Mar 7, 2006·Journal of Pediatric Surgery·Daniel Guimarães BittencourtLourenço Sbragia
Sep 30, 2014·American Journal of Obstetrics and Gynecology·Frances L L GonçalvesLourenço Sbragia
Jun 20, 2007·Pediatric Surgery International·L Cara Jager, Hugo A Heij
Nov 2, 2005·Fetal Diagnosis and Therapy·Antonio Roberto Franchi-TeixeiraLourenço Sbragia

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