Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines

European Journal of Immunology
Bapi PaharRonald S Veazey

Abstract

Peripheral blood and intestinal CD4+CD8+ double-positive (DP) T cells have been described in several species including humans, but their function and immunophenotypic characteristics are still not clearly understood. Here we demonstrate that DP T cells are abundant in the intestinal lamina propria of normal rhesus macaques (Macaca mulatta). Moreover, DP T cells have a memory phenotype and are capable of producing different and/or higher levels of cytokines and chemokines in response to mitogen stimulation compared to CD4+ single-positive T cells. Intestinal DP T cells are also highly activated and have higher expression of CCR5, which makes them preferred targets for simian immunodeficiency virus/HIV infection. Increased levels of CD69, CD25 and HLA-DR, and lower CD62L expression were found on intestinal DP T cells populations compared to CD4+ single-positive T cells. Collectively, these findings demonstrate that intestinal and peripheral blood DP T cells are effector cells and may be important in regulating immune responses, which distinguishes them from the immature DP cells found in the thymus. Finally, these intestinal DP T cells may be important target cells for HIV infection and replication due to their activation, memory...Continue Reading

References

May 1, 1983·Scandinavian Journal of Haematology·C S ScottB E Roberts
Mar 15, 1993·Biochemical and Biophysical Research Communications·C OrtolaniA Cossarizza
Mar 1, 1997·Clinical Immunology and Immunopathology·R S VeazeyA A Lackner
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·L FlamandR C Gallo
Dec 17, 1998·European Journal of Gastroenterology & Hepatology·M AbuzakoukC O'Farrelly
Jun 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·H AkariY Yoshikawa
Feb 13, 2001·Developmental and Comparative Immunology·G I Solano-AguilarJ K Lunney
Nov 8, 2001·Trends in Immunology·R S VeazeyA A Lackner
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine J PitcherLouis J Picker
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva JiménezAlberto Varas
Jul 30, 2003·Journal of Virology·Ronald S VeazeyAndrew A Lackner
May 4, 2004·Nature Reviews. Immunology·Klaus Ley, Geoffrey S Kansas
Sep 15, 2004·The Journal of Experimental Medicine·Jason M BrenchleyDaniel C Douek
Sep 24, 2004·The Journal of Experimental Medicine·Ronald S Veazey, Andrew A Lackner
Oct 28, 2004·Biochemical Society Transactions·A Ivetic, A J Ridley
Jan 1, 2005·Inflammatory Bowel Diseases·Konstantinos A PapadakisStephan R Targan

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Citations

May 24, 2012·Mucosal Immunology·Yang XiCharani Ranasinghe
May 15, 2008·Viral Immunology·David VerhoevenDonna L Farber
Jul 23, 2013·The Journal of Clinical Investigation·Anthony J BonitoKonstantina Alexandropoulos
Mar 14, 2012·PloS One·Kjell EneslättAnders Sjöstedt
Oct 25, 2008·Leukemia & Lymphoma·Aliyah RahemtullahRobert P Hasserjian
Jun 13, 2014·Scandinavian Journal of Gastroenterology·Johanna SundinRobert J Brummer
May 31, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Arpita DasBapi Pahar
Aug 4, 2007·International Immunopharmacology·Ema PaulovicováSlavomír Bystrický
Jul 18, 2014·Lung·Angel J Balam-MayMarco A Vega-López
Apr 10, 2009·International Journal of Cancer. Journal International Du Cancer·Juliette DesfrançoisNadine Gervois
Feb 13, 2007·Immunological Reviews·Dina Montufar-SolisJohn R Klein
Sep 17, 2011·European Journal of Haematology·Claudio FozzaMaurizio Longinotti
Mar 2, 2016·Journal of Crohn's & Colitis·Anna CarrascoFernando Fernández-Bañares
May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ryan Remy BrinkmanClay Smith
Dec 17, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Gregory M SindbergSabita Roy
Feb 23, 2019·Cellular & Molecular Immunology·Hongdi MaShu Zhu
Apr 11, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rawleigh HoweCara C Wilson
Mar 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc A FrahmGuido Ferrari
Jun 27, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Bapi PaharGregory J Bagby
Sep 23, 2020·PloS One·Amber K VirdiLena Al-Harthi

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