Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases.

Frontiers in Immunology
Eric MariettaJoseph A Murray

Abstract

Recent studies have shown that a number of common autoimmune diseases have perturbations of their intestinal microbiome (dysbiosis). These include: Celiac Disease (CeD), Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Sjogren's Syndrome (SS), and Type 1 diabetes (T1D). All of these have intestinal microbiomes that are different from healthy controls. There have been numerous studies using animal models of single probiotics (monoclonal) or mixtures of probiotics (polyclonal) and even complete microbiota transfer (fecal microbial transfer-FMT) to inhibit or delay the onset of autoimmune diseases such as the aforementioned common ones. However, proportionally, fewer clinical trials have utilized monoclonal therapies or FMT than polyclonal therapies for treating autoimmune diseases, even though bacterial mono-therapies do inhibit the development of autoimmune diseases and/or delay the onset of autoimmune diseases in rodent models of those autoimmune diseases. In this review then, we review the previously completed and currently ongoing clinical trials that are testing bacterial therapies (FMT, monoclonal, and polyclonal) to treat common autoimmune dseases and discuss the successes in using bacterial monotherapies to treat roden...Continue Reading

References

Apr 2, 2008·Vaccine·Catharina B M Maassen, Eric Claassen
Aug 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hanneke van der KleijJohn Bienenstock
Dec 17, 2008·Annals of the New York Academy of Sciences·Maria Fischer, Marc Ehlers
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Inge L HuibregtseJoseph A Murray
Jun 23, 2010·BMC Microbiology·Serena SchippaMaria Pia Conte
Jun 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marcus J ClaessonPaul W O'Toole
Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth LauJoseph Larkin
Jun 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Maria de Los Angeles PinedaGregor Reid
Apr 10, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Bernadeta NowakJanusz Marcinkiewicz
Jun 14, 2012·PLoS Pathogens·Seong Gyu JeonKiyoshi Takeda
Jan 11, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ricardo ValladaresClaudio F Gonzalez
Mar 21, 2013·The American Journal of Gastroenterology·Zain KassamRichard H Hunt
Jul 10, 2013·Applied and Environmental Microbiology·Ester SánchezYolanda Sanz
Jan 23, 2014·Scientific Reports·María Esther Mejía-LeónAna María Calderón de la Barca
Oct 16, 2014·International Journal of Biological Macromolecules·Himanshu K SolankiChirag A Patel
Jul 3, 2015·Digestive Diseases and Sciences·Martina KlemenakDušanka Mičetić-Turk
Aug 27, 2015·Microbiome·Emily B HollisterJames Versalovic
Apr 6, 2016·The American Journal of Gastroenterology·Valeria D'ArgenioLucia Sacchetti
Jun 24, 2016·Arthritis & Rheumatology·Eric V MariettaVeena Taneja
Jun 28, 2016·Scientific Reports·Jun ChenAshutosh K Mangalam
Aug 10, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily J AnstadtRobert B Clark
Aug 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Joanna HarnettMargaret Rolfe
Sep 28, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ebrahim KouchakiZatollah Asemi
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Silvia PellegriniLorenzo Piemonti
Mar 31, 2017·Genome Medicine·Jennifer C StearnsUNKNOWN NutriGen Alliance
May 26, 2017·European Journal of Immunology·Kumaraswamy Naidu ChitralaMitzi Nagarkatti

❮ Previous
Next ❯

Citations

Mar 7, 2021·Viruses·Marco QuagliaVincenzo Cantaluppi
May 11, 2021·Frontiers in Immunology·Yusuke Kinashi, Koji Hase
Jun 22, 2021·Frontiers in Immunology·Ivana StojanovićNada Pejnović
Jul 6, 2021·Current Opinion in Endocrine and Metabolic Research·Nita H Salzman, Jeffrey B Schwimmer

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
motility assay

Clinical Trials Mentioned

NCT04014413
NCT03183869
NCT03975413
NCT04150549
NCT03944096
NCT03926286
NCT03840538
NCT04124211
NCT03961347
NCT03032354

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.