PMID: 205506Mar 1, 1978

Intestinal enzyme activities in germfree, conventional, and gnotobiotic rats associated with indigenous microorganisms

Infection and Immunity
Y Kawai, M Morotomi

Abstract

Various enzyme activities involved in the active transport system, glycolysis, and digestion were assayed in various parts of the gastrointestinal tracts of germfree, conventional, and gnotobiotic rats associated with indigenous bacteria. The activity levels of alkaline phosphatase, glucose 6-phosphatase, adenosine triphosphatase, and disaccharidases in the upper small intestine were highest in all parts of the gastrointestinal tracts of various kinds of gnotobiotic, conventional, and germfree rats. Alkaline phosphatase, glucose 6-phosphatase, and adenosine triphosphatase activities in the upper small intestine of germfree rats were, respectively, 2.3-, 2.9-, and 1.7-fold higher than those in conventional rats. Similar to the results of these enzymes, sucrase, maltase, trehalase, and lactase activities in the upper small intestine of germfree rats were, respectively, 1.6-, 1.5-, 2.3-, and 1.8-fold higher than those in conventional rats. In various gnotobiotic rats, enzyme activity levels were intermediate between those in germfree and conventional rats. These findings suggest that those enzymatic activities are strongly depressed by the association with the indigenous microorganisms in the epithelial mucosa of the upper small i...Continue Reading

Citations

Jan 1, 1987·Die Nahrung·M E Coates
Jul 29, 2008·Folia Microbiologica·S MozesV Kmet
Apr 1, 1989·European Journal of Drug Metabolism and Pharmacokinetics·K Pelkonen, P Ylitalo
Jan 1, 1981·Microbiology and Immunology·T WatanabeM Mutai

Related Concepts

DNA-dependent ATPase
Alkaline Phosphatase
Gastrointestinal System
Disaccharidases
Gnotobiotics
Glucosephosphatase
Hexokinase 2
Lactate Dehydrogenase
Lactobacillus
R-Type Pyruvate Kinase

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