Intestinal epithelial cells both express and respond to interleukin 15

Gastroenterology
H C ReineckerD K Podolsky

Abstract

Interleukin (IL)-15 exerts functional effects on lymphocytes similar to those of IL-2. IL-15 is expressed by nonlymphoid cells and may integrate these cells into classical immune responses. The aim of this study was to characterize the expression of IL-15 by intestinal epithelial cells and determine the functional roles of IL-15 within the mucosal immune system. Rat IL-15 was cloned from a rat jejunal library. Expression of IL-15 in rat and human intestinal epithelial cells was assessed by Northern and Western blotting. Tyrosine kinase activation in response to IL-15 in intestinal epithelial cells was determined by immunoprecipitation. Rat and human intestinal epithelial cells express IL-15 messenger RNA. IL-15 activates Stat3 and stimulates the proliferation of intestinal epithelial cells. The relevance of the observations for intestinal epithelial cell function in vivo was supported by the demonstration of transcripts for IL-15 in primary human intestinal epithelial cells. IL-15 is expressed by intestinal epithelial cells function. These experiments suggest that IL-15 is an important mediator that could integrate intestinal epithelial cell function with the intestinal immune system.

Citations

Jan 1, 1997·Springer Seminars in Immunopathology·A D Christ, R S Blumberg
Jun 2, 2005·Springer Seminars in Immunopathology·Lars Eckmann, Martin F Kagnoff
Apr 11, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rachel J Gibson, Dorothy M K Keefe
Oct 8, 2005·Journal of Gastroenterology·Takeshi ShibaharaNaomi Tanaka
Jun 25, 2013·Cytokine & Growth Factor Reviews·Danilo PagliariFranco Pandolfi
Apr 17, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·G BolteM Stern
Mar 21, 1998·International Journal for Parasitology·R FayerD Zarlenga
Mar 16, 2000·Developmental and Comparative Immunology·C H YunE P Lillehoj
Jun 29, 2002·Veterinary Immunology and Immunopathology·Wongi MinTadashi Miyamoto
Dec 5, 1998·Brain Research. Molecular Brain Research·M PrinzF Kirchhoff
Dec 10, 1998·Toxicology·R J VandebrielC Meredith
Jun 23, 1999·FEMS Immunology and Medical Microbiology·F LuzzaF Pallone
May 14, 1999·Trends in Biochemical Sciences·J de la CruzP Linder
Dec 22, 1999·Alimentary Pharmacology & Therapeutics·P J Rutgeerts
Jan 20, 1999·Alimentary Pharmacology & Therapeutics·F M WardR V Heatley
May 3, 2000·Alimentary Pharmacology & Therapeutics·M K VuA A Masclee
Sep 21, 2001·Alimentary Pharmacology & Therapeutics·K Ragunath, J G Williams
Jul 27, 2001·Clinical and Experimental Immunology·M C AldhousS Ghosh
Mar 1, 2002·Immunology and Cell Biology·Lucy Golden-Mason, Cliona O'Farrelly
Apr 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kimberly S SchlunsHector L Aguila
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·N AzimiT A Waldmann
Mar 8, 2000·The Journal of Experimental Medicine·A MaJ P Lodolce
Mar 8, 2000·The Journal of Experimental Medicine·M K KennedyJ J Peschon
Feb 25, 2009·The Journal of Experimental Medicine·Fangming TangBana Jabri
Oct 7, 2006·Current Opinion in Gastroenterology·A K BhanA Mizoguchi
Nov 5, 1999·Critical Care Medicine·V Lazaron, D L Dunn
Mar 22, 2002·Journal of Clinical Gastroenterology·Seymour Katz
Mar 10, 2001·Inflammatory Bowel Diseases·A U Dignass

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.