PMID: 11902446Mar 21, 2002Paper

Intestinal epithelial lesions associated with signet ring cell carcinoma of the colon and small intestine

Pathology
Kien T MaiWilliam Parks

Abstract

The purpose of this study was to investigate the epithelial lesions associated with signet ring cell carcinoma (SRCC) of the colon and small intestine and the possible mechanism of tumour development. Twenty-seven cases of adenocarcinoma with a signet ring cell (SRC) component of the colon and small intestine were divided into three groups depending on the association of the SRCC with: (1) epithelium without definite epithelial dysplasia, (2) adenoma, and (3) common type of adenocarcinoma (CTCA) with SRCC component occupying more than 50%, 30%, or less than 30% of the tumour. Most carcinomas were of T3 or T4 type, using the TNM standard staging system. The SRCC component was histopathologically similar in all groups. In group 1 (four cases, linitis plastica type), the overlying epithelium was normal or showed indefinite epithelial dysplasia and occasionally contained intra-epithelial SRCs. In groups 2 and 3 (two and 21 cases, respectively), seven cases contained multiple foci of intra-epithelial SRCs in areas separated from the invasive carcinoma. Transitional areas between SRCC and adenoma or CTCA were also identified. Immunostaining for p53 showed a varied extent of positive reactivity in 23 SRCC. The degree and the extent of...Continue Reading

References

Nov 1, 1995·Diseases of the Colon and Rectum·L MesseriniG Zampi
Oct 1, 1994·Cancer·K ShirouzuT Kakegawa
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Citations

Aug 6, 2010·International Journal of Colorectal Disease·Vinod GopalanAlfred King-Yin Lam
Jun 27, 2006·Journal of Clinical Pathology·Signe Ledou NielsenIan Talbot
Dec 3, 2014·Gastroenterología y hepatología·Antonio Díaz-SánchezRocío Campos
Jan 15, 2005·Pathology, Research and Practice·L UrievB Yoffe
Jun 25, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·H E AchneckW E Longo
Feb 8, 2020·Indian Journal of Pathology & Microbiology·Sunitha Jacob, Najah R Zayyani
Oct 22, 2003·Archives of Pathology & Laboratory Medicine·Tarek A BismarHanlin L Wang

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