Intestinal Fatty Acid Binding Protein as a Marker of Necrosis and Severity in Acute Pancreatitis

Pancreas
Juozas KupcinskasSara Regnér

Abstract

The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). In a prospective multicenter cohort study, plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. Admission levels of plasma i-FABP were significantly higher in patients with pancreatic necrosis, in patients having systemic complications, in patients treated invasively, in patients treated in the intensive care unit, in patients with severe AP, and in deceased patients. Plasma i-FABP levels on admission yielded an area under curve (AUC) of 0.732 in discriminating patients with or without pancreatic necrosis and AUC of 0.669 in predicting severe AP. Combination of levels of i-FABP and venous lactate on the day of admission showed higher discriminative power in severe AP-AUC of 0.808. Higher i-FABP levels on admission were associated with pancreatic necrosis, systemic complications, and severe AP. Low levels of i-FABP had a high negative predictive value for pancreatic necrosis and severe AP. Combination of levels of i-FABP and venous lactates on admission were superior to either of markers used ...Continue Reading

References

Sep 1, 1992·Digestive Diseases and Sciences·T KandaT Muto
Jul 1, 1991·The Journal of Surgical Research·N S RunkelT A Miller
Jul 27, 2001·The American Journal of Gastroenterology·P G LankischA B Lowenfels
Feb 1, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sakhawat H RahmanMichael J McMahon
May 9, 2007·Gastroenterology·Chris E ForsmarkUNKNOWN AGA Institute Governing Board
Dec 7, 2007·The Surgical Clinics of North America·Mohammed ElfarA Osama Gaber
Jan 19, 2008·Regulatory Peptides·Alicja Wiercinska-DrapaloDanuta Prokopowicz
Jun 26, 2009·World Journal of Gastroenterology : WJG·Alfredo F TonsiClaudio Bassi
Oct 29, 2009·The American Journal of Gastroenterology·Georgios I PapachristouDavid C Whitcomb
Jan 20, 2011·Annals of Surgery·Geertje ThuijlsMartijn Poeze
Jun 28, 2012·World Journal of Gastrointestinal Pathophysiology·Dulce M Cruz-SantamaríaManuel Giner
Sep 14, 2012·Journal of Clinical Gastroenterology·Gabriele CapursoGianfranco Delle Fave
Oct 27, 2012·Gut·Peter A BanksUNKNOWN Acute Pancreatitis Classification Working Group
Mar 16, 2013·European Journal of Gastroenterology & Hepatology·Filipe S CardosoJoão R Deus
Apr 30, 2013·Gastroenterology·Dhiraj Yadav, Albert B Lowenfels
Oct 1, 2013·Journal of Pediatric Surgery·Bhani K Chawla, Daniel H Teitelbaum
Aug 19, 2014·World Journal of Gastrointestinal Pathophysiology·Veit PhillipHana Algül
Jan 27, 2015·Lancet·Paul Georg LankischPeter A Banks

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Citations

Sep 25, 2021·Scientific Reports·Alexandre NuzzoUNKNOWN SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center)

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