Abstract
Acute heart failure and cardiogenic shock are associated with an impaired intestinal perfusion, which may lead to a release of cytoplasmatic proteins by hypoxic epithelial injury. Intestinal fatty acid binding protein (iFABP), highly specific for the small bowel enterocyte, may pose a useful novel and very sensitive biomarker for predicting outcome of these patients.The aim of this study was to investigate whether circulating levels of iFABP are associated with mortality in patients with acute heart failure or cardiogenic shock requiring intensive care unit (ICU) admission. We included 90 consecutive patients with cardiogenic shock (74.4%) or severe acute heart failure (25.6%) admitted to a cardiac ICU. Blood samples were taken at day 0 and day 3. Median age was 64.7 (49.4-74.3), 76.7% of patients were male and median NT-proBNP levels were 4,986 (1,525-23,842) pg/mL. 30-day survival was 64.4%. Patients with serum levels of iFABP at day 0 in the highest quartile (iFABP ≥ 588.4 pg/mL) had a 2.5-fold risk (P = 0.02) of dying independent of demographics, NT-proBNP levels, and vasopressor use. Extensively elevated admission levels of iFABP above the 90th percentile (iFABP ≥ 10208.4 pg/mL) were associated with an excessive mortality ...Continue Reading
References
May 1, 1994·Journal of the American College of Cardiology·S AbeK Kiyonaga
Sep 28, 2002·Critical Care Medicine·Alexander GeppertGottfried Heinz
Jun 25, 2003·Circulation·Judith S Hochman
May 26, 2004·Archives of Internal Medicine·W Andrew OldenburgCharles D Burger
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Jun 16, 2006·Critical Care Medicine·Alexander GeppertKurt Huber
Feb 14, 2009·Journal of the American College of Cardiology·Wilfried MullensW H Wilson Tang
Jun 10, 2009·Intensive Care Medicine·Valentin FuhrmannChristian Madl
Apr 13, 2010·Journal of Critical Care·Frank M P van HarenJohannes G van der Hoeven
Jan 20, 2011·Annals of Surgery·Geertje ThuijlsMartijn Poeze
Jun 30, 2012·Resuscitation·D GrimaldiA Cariou
Aug 28, 2012·The New England Journal of Medicine·Holger ThieleUNKNOWN IABP-SHOCK II Trial Investigators
Jun 21, 2013·Critical Care Medicine·Gaël PitonGilles Capellier
Jul 27, 2014·Heart Failure Reviews·Pasqualina L SantaguidaParminder Raina
Dec 3, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Angela M Gajda, Judith Storch
Jan 7, 2015·The American Journal of Gastroenterology·Lawrence J BrandtUNKNOWN American College of Gastroenterology
Oct 9, 2015·Critical Care Medicine·Konstantin A KrychtiukWalter S Speidl
May 22, 2016·European Heart Journal·Piotr PonikowskiUNKNOWN ESC Scientific Document Group
Oct 30, 2016·Thrombosis and Haemostasis·Konstantin A KrychtiukWalter S Speidl
Nov 20, 2016·Annals of Intensive Care·Simon BourcierFrédéric Pène
Citations
Feb 17, 2019·Clinical and Experimental Immunology·X TengL Morel
Mar 15, 2019·Shock·Matthias Majetschak
May 23, 2019·Current Opinion in Critical Care·Georg Fuernau
Jun 9, 2020·Experimental and Therapeutic Medicine·Yang Peng, Han Wei
Feb 23, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·Johannes SzaszMartin Dünser
Feb 23, 2021·Journal of Cardiac Surgery·Jenny SeilitzKristofer F Nilsson
Jun 12, 2020·Resuscitation·Konstantin A KrychtiukWalter S Speidl