Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel: results from a multicenter study

Journal of Pediatric Surgery
F H HeidaThomas M Benkoe

Abstract

Intestinal fatty acid-binding protein (I-FABP) is considered as a specific marker for enterocyte damage in necrotizing enterocolitis (NEC). The purpose of this study was to evaluate the association of plasma and urinary I-FABP levels with the extent of macroscopic intestinal necrosis in surgical NEC. We combined data from prospective trials from two large academic pediatric surgical centers. Nine and 10 infants with surgical NEC were included, respectively. Plasma and urinary of I-FABP at disease onset were correlated with the length of intestinal resection during laparotomy. Median length of bowel resection was 10cm (range 2.5-50) and 17cm (range 0-51), respectively. Median I-FABP levels were 53ng/mL (range 6.3-370) and 4.2ng/mL (range 1.1-15.4) in plasma in cohort 1 respectively cohort 2 and 611ng/mL (range 3-23,336) in urine. The length of bowel resection significantly correlated with I-FABP levels in plasma (Rho 0.68; p=0.04 and Rho 0.66;p=0.04) and in urine (Rho 0.92; p=0.001). This 'proof of concept' study demonstrates that plasma and urine I-FABP levels at disease onset was strongly associated with the length of intestinal resection in surgical NEC. This offers further evidence that I-FABP levels are a promising biomarke...Continue Reading

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Citations

Mar 1, 2016·Early Human Development·Simon EatonNigel J Hall
Oct 25, 2016·American Journal of Surgery·Shokei MatsumotoMitsuhide Kitano
Aug 19, 2016·Nature Reviews. Gastroenterology & Hepatology·Diego F NiñoDavid J Hackam
Mar 31, 2018·Current Opinion in Pediatrics·Mubina A IsaniHenri R Ford
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Jun 11, 2019·Gastroenterology Research and Practice·Kewei WangKarl G Sylvester
Jul 27, 2018·Italian Journal of Pediatrics·Gabriella D'AngeloEloisa Gitto
Aug 2, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bhawan Deep GargAnju Bansal
Jun 7, 2021·Journal of Pediatric Surgery·George S BethellUNKNOWN BAPS-CASS NEC Investigator Group on behalf of BAPS-CASS
May 6, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Grace YoonRobert S Chapkin

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