Intestinal fermentation in vitro models to study food-induced gut microbiota shift: an updated review.

FEMS Microbiology Letters
Lorenzo NissenAndrea Gianotti

Abstract

In vitro gut fermentation models were firstly introduced in nutrition and applied microbiology research back in the 1990s. These models have improved greatly during time, mainly over the resemblance to the complexity of digestion stages, the replication of experimental conditions, the multitude of ecological parameters to assay. The state of the science is that the most competitive models shall include a complex gut microbiota, small working volumes, distinct interconnected compartments and rigorous bio-chemical and ecological settings, controlled by a computer, as well as a free-hands accessibility, not to contaminate the mock microbiota. These models are a useful tool to study the impact of a given diet compound, e.g. prebiotics, on the human gut microbiota. The principal application is to focus on the shift of the core microbial groups and selected species together with their metabolites, assaying their diversity, richness and abundance in the community over time. Besides, it is possible to study how a compound is digested, which metabolic pathways are triggered, and the type and quantity of microbial metabolites produced. Further prospective should focus on challenges with pathogens as well as on ecology of gut syndromes. I...Continue Reading

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Citations

Feb 3, 2021·The Journal of Microbiology·Vineet SinghUnno Tatsuya
Mar 16, 2021·Applied Microbiology and Biotechnology·Namiko HoshiKengo Sasaki
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carmen van der LindeAdele Costabile
Jul 3, 2021·Marine Drugs·Emer ShannonMaria Hayes
Jul 24, 2021·Biotechnology and Bioengineering·Salam HabibLuis B Agellon
Aug 15, 2021·Advanced Drug Delivery Reviews·Connor O'FarrellHannah Batchelor

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