PMID: 19916949Nov 18, 2009Paper

Intestinal fibrosis in Crohn's disease: medical treatment or surgery?

Current Drug Targets
Antonino SpinelliMarco Montorsi

Abstract

Crohn's disease (CD) is a chronic panenteric disease of unknown aethiology tending to progress, inspite medical or surgical treatment. Intestinal fibrosis is among the most common complications of CD, resulting in stricture formation in the small intestine and colon. About 75% of CD patients will undergo surgery at least once over the course of their disease and fibrotic strictures represents the main indication for surgery and the first cause of hospitalization and costs for CD patients. Clinical management of intestinal strictures depends on the type of stricture: inflammatory strictures are treated medically and are usually responsive to treatment, while fibrotic strictures require surgery. Clinical decisions regarding the right treatment choice for such conditions require proper knowledge on what to expect from the emerging drug strategies and surgical techniques. To achieve optimal results in patients management an approach combining the expertise of both gastroenterologist and colorectal surgeon is essential. This review aims at providing clinicians with an overview on fibrotic strictures in CD patients particular focus will be placed on the principal imaging modalities, and the medical, endoscopic and surgical treatment ...Continue Reading

Citations

Sep 18, 2010·Inflammatory Bowel Diseases·V Anik Sahni, Paul B Shyn
Aug 10, 2012·World Journal of Gastroenterology : WJG·Giovanni Latella, Claudio Papi
Feb 2, 2012·World Journal of Gastroenterology : WJG·Ferenc SiposBéla Molnár
Apr 1, 2014·Fibrogenesis & Tissue Repair·Dominik Bettenworth, Florian Rieder
Jan 29, 2011·Journal of Crohn's & Colitis·Giovanni LatellaSimon Travis
Dec 20, 2014·Scandinavian Journal of Gastroenterology·Giovanni LatellaIan C Lawrance
Nov 8, 2016·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Lin Hai KuraharaRyuji Inoue
Aug 19, 2016·United European Gastroenterology Journal·Noam JacobDavid Q Shih
Sep 4, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Davide FerrariBruce Cronstein
Apr 13, 2020·Digestive Diseases and Sciences·Mattia CrespiMassimo Conio
Jun 23, 2020·Immunity, Inflammation and Disease·Brecht CreynsChristine Breynaert
Nov 6, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Fernando Mendonça VidigalJulio Maria Fonseca Chebli
Oct 28, 2019·International Journal of Molecular Sciences·Alessandro Alaimo, Josep Rubert
Jun 7, 2020·International Journal of Colorectal Disease·Irene MarafiniGiovanni Monteleone
Jun 9, 2017·BMC Gastroenterology·Jun Bon KooJun Hwan Yoo
Jan 17, 2020·Inflammatory Bowel Diseases·Raditya IswandanaPeter Olinga

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