Intestinal GLUT5 and FAT/CD36 transporters and blood glucose are reduced by a carotenoid/MUFA-rich oil in high-fat fed mice.

Life Sciences
Paulo Henrique Evangelista-SilvaElizabethe Adriana Esteves

Abstract

Intestinal nutrient absorption plays a vital role in developing obesity, and nutrient transporters expressed in the enterocytes facilitate this process. Moreover, previous studies have shown that specific foods and diets can affect their cell levels. Herein, we investigated the effects of pequi oil (PO), which is high in several bioactive compounds, on intestinal nutrient transporter levels as well as on intestinal morphology and metabolic biomarkers. Groups of male C57BL/6 mice were fed either a standard (C) or a high-fat diet (HFD) and pequi oil (CP and HFDP with PO by gavage at 150 mg/day) for eight weeks. Food intake and body weight were monitored, serum metabolic biomarkers, intestinal transporter levels and histological analyses were performed. PO increased caloric intake without increasing body or fat mass regardless of diet. The HFD group treated with PO reduced fasting blood glucose and villus width. PO did not affect GLUT2, L-FABP, FATP4, NPC1L1, NHE3 or PEPT1 content in CP or HFDP groups. GLUT5 and FAT/CD36 levels were reduced in both CP and HFDP. Our data suggest that PO attenuated monosaccharide and fatty acid absorption, contributing to lower fasting glycemia and higher food intake without affecting body weight or...Continue Reading

References

Mar 1, 1980·Diabetes Care·R S Sherwin
Apr 21, 2005·The Journal of Clinical Investigation·Victor A DroverNada A Abumrad
Jan 18, 2006·Drug Metabolism and Pharmacokinetics·Chizuru WatanabeAkira Tsuji
May 1, 2007·Experimental Physiology·David T Thwaites, Catriona M H Anderson
Mar 21, 2008·The Journal of Biological Chemistry·Jill SmithNada A Abumrad
Dec 19, 2008·The Journal of Biological Chemistry·Sharon BaroneManoocher Soleimani
Sep 26, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ana GuijarroDaniele Piomelli
Mar 9, 2010·Analytical Biochemistry·Isabel Romero-CalvoFermín Sánchez de Medina
Oct 30, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Guillaume DalmassoDidier Merlin
Nov 2, 2011·Acta Cirúrgica Brasileira·Monike Garlipp PicchiAlceu Afonso Jordão
Jul 20, 2012·Physiological Reviews·Nada A Abumrad, Nicholas O Davidson
Apr 20, 2014·The Journal of Nutritional Biochemistry·Reilly T EnosE Angela Murphy
Oct 7, 2014·Journal of Proteome Research·Jacek R WiśniewskiHermann Koepsell
Jul 23, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N B R ColomboV L Capelozzi
Aug 20, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Simone M PalmeiraFrancisco J Hernandez-Blazquez
Oct 7, 2015·BMC Complementary and Alternative Medicine·Kyung-A HwangJeong-Sook Choe
Apr 19, 2016·Best Practice & Research. Clinical Gastroenterology·Pawel R Kiela, Fayez K Ghishan
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lucillia R de O TorresJorge Mancini-Filho
May 31, 2017·Journal of Medicinal Food·Giseli Karenina TraeselSilvia Aparecida Oesterreich
Nov 21, 2017·The Medical Clinics of North America·Jagriti UpadhyayChristos Mantzoros
Feb 8, 2018·Cell Metabolism·Cholsoon JangJoshua D Rabinowitz
Apr 8, 2018·Life Sciences·Mariana Cerqueira LosaccoFrancemilson Goulart-Silva
May 29, 2018·Food Research International·Nicola CiceroGiacomo Dugo
Dec 8, 2019·Biochemical and Biophysical Research Communications·Shohei TanakaMamoru Watanabe

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