Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy

Journal of Hepatology
Manuel Romero-GómezJuan D Bautista

Abstract

We performed the current study to assess the intestinal activity of enterocyte phosphate-activated glutaminase (PAG) in cirrhosis. Forty-nine cirrhotic patients and 36 control subjects underwent endoscopic duodenal biopsies. Minimal hepatic encephalopathy (MHE) was evaluated using three psychometric tests. Oral glutamine challenge (OGC) was performed and MELD, Child-Pugh and the presence of esophageal varices were recorded. PAG was measured by enzymatic methods. Cerebral magnetic resonance spectroscopy was performed in 10 cirrhotics. PAG was found to be higher in cirrhotics than control subjects 2.4+/-1.51 vs. 0.68+/-0.57IU/mg protein (P<0.001). PAG was also increased in patients with MHE and correlated with MELD, INR, esophageal varices and serum bile acids. A negative correlation was observed between PAG activity and intra-cerebral choline/creatine ratio (r=-0.67; P=0.035) and a positive correlation with glutamine plus glutamate/creatine ratio (r=0.78; P=0.007). In multivariate analysis using backward logistic regression, presence of MHE was the only variable independently related to altered enterocyte PAG. Enterocyte PAG is increased in cirrhotic patients and correlates with MHE. These data support a possible role for intest...Continue Reading

References

Aug 1, 1977·Archives of Biochemistry and Biophysics·L M Pinkus, H G Windmueller
Jul 15, 1985·The Biochemical Journal·W G HaserN P Curthoys
Nov 22, 1973·The New England Journal of Medicine·J MarcoJ M Segovia
Nov 1, 1971·Annals of Surgery·F C Nance, D G Kline
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K N OppongC O Record
May 4, 1999·The International Journal of Biochemistry & Cell Biology·R McCauleyJ C Hall
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AmodioA Gatta
Aug 19, 2000·The American Journal of Gastroenterology·I J HartmannS W Schalm
Mar 27, 2001·Biochimica Et Biophysica Acta·L TaylorN P Curthoys
May 15, 2001·Journal of Gastroenterology and Hepatology·A DasS R Naik
Sep 25, 2001·The American Journal of Gastroenterology·M Romero-GómezJ Aguilar-Reina
Apr 6, 2002·Nutrition·Malcolm WatfordPriya Raman
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven W M Olde DaminkPeter B Soeters
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sherzad BalataRajiv Jalan
Feb 1, 1993·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M Elia

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Citations

Nov 4, 2006·Current Treatment Options in Gastroenterology·Nader Dbouk, Brendan M McGuire
Feb 1, 2005·Lancet·Debbie Shawcross, Rajiv Jalan
Feb 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Giannakis T TorisStamatios E Theocharis
Jul 2, 2015·Biological Trace Element Research·Abdelrahman A KobtanMohamed A Goda
Jun 26, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Matthew R Kappus, Jasmohan S Bajaj
May 1, 2012·Clinics in Liver Disease·Vandana Khungar, Fred Poordad
May 13, 2008·Gastroenterology·Arun J SanyalVincente Arroyo
Jan 16, 2007·Best Practice & Research. Clinical Gastroenterology·Gavin Wright, Rajiv Jalan
May 25, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Mireia MiquelRamon Planas
Aug 3, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Gavin WrightRajiv Jalan
Oct 19, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Lorette NoiretRajiv Jalan
May 7, 2013·Biochimica Et Biophysica Acta·Suzanne GeenenHans V Westerhoff
Jul 22, 2015·Clinics in Liver Disease·Robert S Rahimi, Don C Rockey
Jul 22, 2015·Clinics in Liver Disease·Catherine Lucero, Elizabeth C Verna
Apr 14, 2015·Mayo Clinic Proceedings·Elliot B TapperVilas R Patwardhan
Jul 9, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Alba MoratallaRubén Francés
Feb 6, 2015·United European Gastroenterology Journal·Markus Peck-RadosavljevicDominique Valla
Sep 20, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Milan Holecek
Oct 31, 2017·Alimentary Pharmacology & Therapeutics·C A WoodhouseD L Shawcross
Feb 1, 2005·World Journal of Gastroenterology : WJG·Lin Jia, Mei-Hua Zhang
Jul 14, 2017·British Journal of Nursing : BJN·Palle Bager
Apr 14, 2010·Expert Opinion on Pharmacotherapy·Manuel Romero-Gómez
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kevin D MullenBrian S Putka
Sep 5, 2009·European Journal of Gastroenterology & Hepatology·Mariano MalaguarneraFabio Galvano
Apr 24, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Charmaine A StewartGlenn E Smith
Dec 31, 2005·Metabolic Brain Disease·Manuel Romero-Gómez
Nov 19, 2013·Expert Review of Gastroenterology & Hepatology·Jonathan P Sturgeon, Debbie L Shawcross
Jan 15, 2014·Journal of Breath Research·B de Lacy CostelloN M Ratcliffe
Nov 28, 2012·Metabolic Brain Disease·Hanan Mardini, Christopher Record
Apr 9, 2005·Current Opinion in Gastroenterology·Guadalupe Garcia-Tsao
Nov 15, 2012·Metabolic Brain Disease·Javier MárquezMercedes Martín-Rufián
Mar 16, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Antonio Gil-GÓmezManuel Romero Gómez
Nov 16, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Javier AmpueroManuel Romero-Gómez
Sep 12, 2007·Metabolic Brain Disease·Marsha Y MorganKarin Weissenborn
Dec 23, 2008·Metabolic Brain Disease·V StadlbauerR Jalan
Oct 9, 2015·Metabolic Brain Disease·Vishal C PatelDebbie L Shawcross
Mar 2, 2019·World Journal of Hepatology·Luiza Cioglia Dias LimaAna Cristina Simões E Silva
May 12, 2006·World Journal of Gastroenterology : WJG·Manuel Romero-GomezJuan-D Bautista
Oct 4, 2016·Metabolic Brain Disease·Luisa BakerNicolaas Deutz
Nov 28, 2012·Metabolic Brain Disease·Javier AmpueroManuel Romero-Gómez
Dec 11, 2008·Metabolic Brain Disease·Manuel Romero-GómezA Ruiz

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